Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity.
Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity.
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DOI：
10.1155/2022/5818612
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发表时间：
2022
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
Anthracyclines are chemotherapeutic agents widely used to treat a variety of cancers, and these drugs have revolutionized our management of cancer patients. The dose-dependent cardiotoxicity of anthracyclines, however, remains one of the leading causes of chemotherapy treatment-associated mortality in cancer survivors. Patient threshold doses leading to anthracycline-induced cardiotoxicity (AIC) are highly variable among affected patients. This variability is largely ascribed to genetic variants in individuals' genomes. Here, we briefly discuss the prevailing mechanisms underlying the pathogenesis of AIC, and then, we review the genetic variants, mostly identified through human genetic approaches and identified in cancer survivors. The identification of all genetic susceptibilities and elucidation of underlying mechanisms of AIC can help improve upfront risk prediction assessment for potentially severe cardiotoxicity disease and provide valuable insights into the understanding of AIC pathophysiology, which can be further leveraged to develop targeted pharmacogenetic therapies for those at high risk.
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影响因子：
5.6
作者：
Cornet C;Di Donato V;Terriente J
通讯作者：
Terriente J
影响因子：
5.4
作者：
Ding Y;Yang J;Chen P;Lu T;Jiao K;Tester DJ;Giudicessi JR;Jiang K;Ackerman MJ;Li Y;Wang DW;Lee HC;Wang DW;Xu X
通讯作者：
Xu X
影响因子：
0.6
作者：
Fogarassy Gyorgy;Fogarassyne Vathy Agnes;Forster Tomas
通讯作者：
Forster Tomas
DOI：
10.1200/edbk_100015
发表时间：
2018-05-23
期刊：
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
影响因子：
--
作者：
Armenian, Saro;Bhatia, Smita
通讯作者：
Bhatia, Smita
影响因子：
45.3
作者：
Armenian, Saro H.;Lacchetti, Christina;Lenihan, Daniel
通讯作者：
Lenihan, Daniel