CD5+ B-CELLS AND CD4-8- T-CELLS IN NEUROIMMUNOLOGICAL DISEASES
CD5+ B-CELLS AND CD4-8- T-CELLS IN NEUROIMMUNOLOGICAL DISEASES
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DOI：
10.1016/0165-5728(91)90004-q
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发表时间：
1991-05-01
影响因子：
3.3
通讯作者：
LINK, H
中科院分区：
文献类型：
--
作者：
CORREALE, J;MIX, E;LINK, H
Using 2- and 3-colour FACS analysis we found increased levels of fetal-type CD5+ B cells and CD4-8- T cells in cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and aseptic meningitis (AM) compared to control probands with muscular tension headache (TH). Similar differences were found for CD5+ B cells in peripheral blood, but at lower levels. CD4-8- T cells in blood exceeded those in CSF in all patient groups, with the exception of relapsing remitting MS, revealing the highest values in AM. There was a positive correlation between CD4-8- T cells and T cell receptor (TCR) gamma-delta bearing T cells in blood and CSF. The double-negative T cells exceeded the TCR gamma-delta T cells by about 1%. A positive correlation between CD5+ B cells and CD4-8- T cell level in CSF was found in MS and AM, but not in TH, nor in blood of any patient group. HLA-DR expression was lower in CD5+ B cells than in CD5- B cells. We conclude that fetal-type lymphocytes are enriched in CSF compartment of patients with inflammatory diseases of the central nervous system, irrespective of autoimmune mechanisms involved, but the function of CD5+ B cells is mainly to produce the autoantibodies.
