Zebrafish (Danio rerio): A newcomer with great promise in behavioral neuroscience
Zebrafish (Danio rerio): A newcomer with great promise in behavioral neuroscience
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DOI：
10.1016/j.neubiorev.2022.104978
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发表时间：
2022-11-29
影响因子：
8.2
通讯作者：
Gerlai, Robert
中科院分区：
文献类型：
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作者：
Gerlai, Robert
行为神经科学是一个跨学科的领域，旨在理解行为的神经生物学。许多研究人员转向动物来模拟和理解脊椎动物大脑功能的机制，包括人类大脑疾病，这些物种与我们有着共同的进化史。在这方面，斑马鱼是一个相对较新的研究物种。然而，正如这篇综述试图证明的那样，它可能在行为神经科学中有一个很好的未来。它是一种简单的脊椎动物，体积小，在实验室里饲养和研究成本低。然而，它与我们自己的物种非常相似，因此，我们能够将其用于翻译和基础研究。在这篇应邀的评论中，我将讨论它的优点和一些缺点，为什么它应该或不应该在研究中使用的原因和反驳。我将重点关注它在行为神经科学中的应用，并将简要介绍斑马鱼研究与国际行为神经科学协会所代表的科学之间的演变历史。
Behavioral neuroscience is an interdisciplinary field aimed at understanding the neurobiology of behavior. Numerous investigators turn to animals to model and understand the mechanisms underlying vertebrate brain function including human brain disorders, species that share evolutionary history with us. The zebrafish is a relatively new study species for such purposes. However, as this review attempts to demonstrate, it will likely have a good future in behavioral neuroscience. It is a simple vertebrate that is small and cheap to keep and study in the laboratory. Yet, it is similar enough to our own species, thus, we are able to use it for both translational as well as basic research. In this invited review, I will discuss its advantages and some of its disadvantages, the reasons and counterarguments why it should or should not be employed in research. I will focus on its utility in behavioral neuroscience, and will also provide a brief historical account of the evolution between zebrafish research and the science represented by the International Behavioral Neuroscience Society.