Reciprocal Thalamocortical Connectivity of the Medial Pulvinar: A Depth Stimulation and Evoked Potential Study in Human Brain
Reciprocal Thalamocortical Connectivity of the Medial Pulvinar: A Depth Stimulation and Evoked Potential Study in Human Brain
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DOI：
10.1093/cercor/bhn185
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发表时间：
2009-06-01
期刊：
影响因子：
3.7
通讯作者：
Magnin, M.
中科院分区：
文献类型：
--
作者：
Rosenberg, D. S.;Mauguiere, F.;Magnin, M.
丘脑内侧枕核(PUM)只有在灵长类动物中才发育完全，在人类中达到最大程度。为了评估PUM和皮质之间的相互功能连接，我们研究了7例癫痫患者在PUM和皮质电刺激后获得的脑内诱发反应，并进行了深度脑电记录。除纹状皮质、扣带前回和中央后回外，其余脑区均记录到刺激PUM的皮层诱发电位(CEP)。对PUM刺激有反应的皮质接触对的百分比(CEPS反应率)从颞叶新皮质、颞顶交界处、岛叶和额顶顶盖皮质的80%到内侧颞区的34%不等。刺激岛叶和额顶顶盖皮质后，PUM诱发电位反应率分别为14%、67%、76%和80%。总体而言，我们对人脑功能PUM连接的研究与大多数来自猴子解剖学研究的数据一致，除了杏仁核-海马体功能投射到PUM的强烈投射，以及所探索的一些相互作用的通路之间意外的失衡。这种功能定量方法有助于阐明PUM的功能作用及其在颞叶癫痫发作中的意义。
The thalamic medial pulvinar nucleus (PuM) is fully developed only in primates and reaches its greatest extent in humans. To assess the reciprocal functional connectivity between PuM and cortex, we studied intracerebral-evoked responses obtained after PuM and cortical electrical stimulation in 7 epileptic patients undergoing depth electroencephalographic recordings. Cortical-evoked potentials (CEPs) to PuM stimulation were recorded from all explored cortical regions, except striate cortex, anterior cingulated, and postcentral gyrus. Percentages of cortical contacts pairs responding to PuM stimulation (CEPs response rate) ranged from 80% in temporal neocortex, temporoparietal (TP) junction, insula, and frontoparietal opercular cortex to 34% in mesial temporal regions. Reciprocally, PuM-evoked potentials (PEPs) response rates were 14% after cortical stimulation in insula and frontoparietal opercular cortex, 67% in the TP junction, 76% in temporal neocortex, and 80% in mesial temporal regions. Overall, our study of functional PuM connectivity in the human brain converges with most of the data from anatomical studies in monkeys, except for a strong amygdalohippocampal functional projection to PuM and an unexpected imbalance between some of the reciprocal pathways explored. This functional quantitative approach helps to clarify the functional role of PuM as well as its implication in temporal lobe epileptic seizures.