Does hyperbaric oxygen (HBO) delivery rescue retinal photoreceptors in retinitis pigmentosa?
Does hyperbaric oxygen (HBO) delivery rescue retinal photoreceptors in retinitis pigmentosa?
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DOI：
10.1023/a:1002015317479
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发表时间：
1999-01-01
影响因子：
1.4
通讯作者：
Rispoli, E
中科院分区：
文献类型：
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作者：
Vingolo, EM;Pelaia, P;Rispoli, E
正如先前文献中所报道的，高压氧治疗似乎可以改变视网膜色素变性的自然病程。为了评估这些最初令人鼓舞的数据，48名受影响的受试者被分成两个亚组(病例组和对照组)分别进行研究。所有患者都进行了年度眼科检查，由最大幅度视网膜电信号完成，根据我们的“微分导数”系统进行，这是一种专门为提高信噪比而设计的新记录技术。根据标准方案，每天定期给氧90分钟(2.2绝对值)，分三个周期进行。两年后(T2)10.7+/-7.6mU V，研究结束时(T3)14.4+/-11.7 mU V，对照组视网膜电信号平均值为4.92+/-3.05 mU V，T1 5.04+/-3.07 mU V；T2为3.46+/-2.77 mV；T3为2.97+/-3.61 mV，波幅差异有统计学意义(P
As previously reported in the literature, hyperbaric oxygen delivery seems to modify the natural course of retinitis pigmentosa. In order to evaluate these first encouraging data, 48 affected subjects were separately studied in two subgroups (cases and controls). All patients underwent yearly an ophthalmological examination completed by a maximum amplitude electroretinogram, conducted according to our 'differential derivation' system, a new recording technique specifically designed to enhance the signal-to-noise ratio. Oxygen delivery was provided regularly for 90 min daily (2.2 Absolute Atmosphere) in three cycles according to a standard protocol. In the cases, electroretinographic mean values were as follows: at TO (basal) 4.68 +/- 3.81 mu V; after one year (T1) 8.46 +/- 5.71 mu V; at two years (T2) 10.7 +/- 7.6 mu V; at the end of the study (T3) 14.4 +/- 11.7 mu V. In the controls, electroretinographic mean values were as follows: at TO 4.92 +/- 3.05 mu V; at T1 5.04 +/- 3.07 mu V; at T2 3.46 +/- 2.77 mu V; at T3 2.97 +/- 3.61 mu V. Amplitudes showed a remarkable (p