Cyclooxygenase metabolites mediate glomerular monocyte chemoattractant protein-1 formation and monocyte recruitment in experimental glomerulonephritis.
Cyclooxygenase metabolites mediate glomerular monocyte chemoattractant protein-1 formation and monocyte recruitment in experimental glomerulonephritis.
复制标题
环加氧酶代谢物介导实验性肾小球肾炎中肾小球单核细胞趋化蛋白-1 的形成和单核细胞的募集。
作者：
A. Schneider;S. Harendza;G. Zahner;T. Jocks;U. Wenzel;G. Wolf;F. Thaiss;U. Helmchen;R. A. Stahl
背景
BACKGROUND
Monocyte chemoattractant protein-1 (MCP-1) has been shown to play a significant role in the recruitment of monocytes/macrophages in experimental glomerulonephritis. Whereas a number of inflammatory mediators have been characterized that are involved in the expression of MCP-1 in renal disease, little is known about repressors of chemokine formation in vivo. We hypothesized that cyclooxygenase (COX) products influence the formation of MCP-1 and affect inflammatory cell recruitment in glomerulonephritis.
METHODS
The effect of COX inhibitors was evaluated in the antithymocyte antibody model and an anti-glomerular basement membrane model of glomerulonephritis. Rats were treated with the COX-1/COX-2 inhibitor indomethacin and the selective COX-2 inhibitors meloxicam and SC 58125. Animals were studied at 1 hour, 24 hours, and 5 days after induction of the disease.
RESULTS
Indomethacin, to a lesser degree the selective COX-2 inhibitors, enhanced glomerular MCP-1 and RANTES mRNA levels. Indomethacin enhanced glomerular monocyte chemoattractant activity an the infiltration of monocytes/macrophages at 24 hours and 5 days.
CONCLUSIONS
Our studies demonstrate that COX products may serve as endogenous repressors of MCP-1 formation in experimental glomerulonephritis. The data suggest that COX-1 and COX-2 products mediate these effects differently because the selective COX-2 inhibitors had less influence on chemokine expression.
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小鼠系膜细胞中 IFN-γ、肿瘤坏死因子-α、IgG 聚集体和 cAMP 对单核细胞趋化蛋白-1 和巨噬细胞集落刺激因子-1 的调节。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Satriano,JA;Hora,K;Shan,Z;Stanley,ER;Mori,T;Schlondorff,D
通讯作者：
Schlondorff,D
影响因子：
56.9
作者：
KOPP, E;GHOSH, S
通讯作者：
GHOSH, S
DOI：
--
发表时间：
1994-10
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Rovin Bh;M. Rumancik;L. Tan;J. Dickerson
通讯作者：
Rovin Bh;M. Rumancik;L. Tan;J. Dickerson
影响因子：
15.9
作者：
SATRIANO, J;SCHLONDORFF, D
通讯作者：
SCHLONDORFF, D
IL-1 对成纤维细胞环氧合酶合成的调节。
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Raz,A;Wyche,A;Siegel,N;Needleman,P
通讯作者：
Needleman,P