Prognostic Value of Neutrophil-Related Factors in Locally Advanced Cervical Squamous Cell Carcinoma Patients Treated with Cisplatin-Based Concurrent Chemoradiotherapy.
Prognostic Value of Neutrophil-Related Factors in Locally Advanced Cervical Squamous Cell Carcinoma Patients Treated with Cisplatin-Based Concurrent Chemoradiotherapy.
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中性粒细胞相关因素对接受顺铂同步放化疗的局部晚期宫颈鳞状细胞癌患者的预后价值
DOI：
10.1155/2016/3740794
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Zhe H
中科院分区：
文献类型：
--
作者：
Wang YY;Bai ZL;He JL;Yang Y;Zhao R;Hai P;Zhe H
本研究旨在探讨局部晚期宫颈鳞状细胞癌（LACSCC）顺铂同步放化疗（CCRT）患者的嗜中性粒细胞-淋巴细胞比率（NLR）和中性粒细胞对粒细胞集落刺激因子（RNG）的反应性等嗜中性粒细胞相关因素与预后的关系。本研究共纳入60例LACSCC患者。我们分析了NLR或RNG与这些患者临床病理特征的关系。采用单因素和多因素生存分析评价预后因素。总生存期（OS）的NLR最佳临界值确定为2.0。较高水平的NLR与年龄较小（P = 0.017）和基线血小板计数较高（P = 0.040）相关。多因素分析显示NLR是影响OS的唯一独立预后因素（P = 0.037）。中位RNG为3.01，范围为1.19-16.84。RNG水平与淋巴结转移显著相关（P = 0.023）。高RNG是影响OS的独立不良预后因素（P = 0.055）。本研究表明，NLR和RNG可作为潜在的生物标志物，用于预测接受CCCRT的LACSCC患者的生存率。
The aim of this study was to explore the relationship between neutrophil-related factors, including neutrophil-lymphocyte ratio (NLR) and the responses of neutrophil to granulocyte colony-stimulating factors (RNG), and the prognosis of patients with locally advanced cervical squamous cell carcinoma (LACSCC) undergoing cisplatin-based concurrent chemoradiotherapy (CCCRT). A total of sixty LACSCC patients were enrolled in this study. We analyzed the association of NLR or RNG with clinicopathologic characteristics of these patients. The prognostic factors were evaluated by univariate and multivariate survival analysis. The optimal cut-off value of the NLR was determined to be 2.0 for the overall survival (OS). A higher level of the NLR was associated with younger age (P = 0.017) and higher baseline platelet count (P = 0.040). NLR was identified to be the only independent prognostic factor for OS by multivariate analysis (P = 0.037). The median RNG was 3.01, with a range of 1.19–16.84. RNG level was significantly associated with lymph node metastasis of these patients (P = 0.023). And higher RNG was identified as being a closely independent poor prognostic factor for OS (P = 0.055). This study showed that NLR and RNG may be used as potential biomarkers for survival prediction in patients with LACSCC receiving CCCRT.