Circadian Control of Global Transcription.
Circadian Control of Global Transcription.
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DOI：
10.1155/2015/187809
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发表时间：
2015
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Li S;Zhang L
昼夜节律存在于地球上的大多数（如果不是全部）生物体中，并体现在生理和行为的各个方面。这些节律过程被认为是由调节时钟控制基因（CCG）节律表达的内源分子时钟驱动的。 CCG 包含基因组的重要部分，并参与多种生物途径。 CCG 的转录是通过转录因子的节律性作用和染色质的昼夜节律变化来调节的。在这里，我们回顾了五种广泛使用的模型生物中 CCG 转录的昼夜节律控制，包括蓝藻、真菌、植物、果蝇和小鼠。比较五种生物体的相似性和差异可以帮助我们更好地了解生物钟的功能及其适应不同环境条件需求的输出机制。
Circadian rhythms exist in most if not all organisms on the Earth and manifest in various aspects of physiology and behavior. These rhythmic processes are believed to be driven by endogenous molecular clocks that regulate rhythmic expression of clock-controlled genes (CCGs). CCGs consist of a significant portion of the genome and are involved in diverse biological pathways. The transcription of CCGs is tuned by rhythmic actions of transcription factors and circadian alterations in chromatin. Here, we review the circadian control of CCG transcription in five model organisms that are widely used, including cyanobacterium, fungus, plant, fruit fly, and mouse. Comparing the similarity and differences in the five organisms could help us better understand the function of the circadian clock, as well as its output mechanisms adapted to meet the demands of diverse environmental conditions.