Mesenchymal stem cells transplantation for systemic lupus erythematosus
Mesenchymal stem cells transplantation for systemic lupus erythematosus
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间充质干细胞移植治疗系统性红斑狼疮
DOI：
10.1111/1756-185x.12531
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发表时间：
2015-02-01
影响因子：
2.5
通讯作者：
Sun, Lingyun
中科院分区：
文献类型：
--
作者：
Liang, Jun;Sun, Lingyun
间充质干细胞是一种罕见的干细胞亚群，存在于骨髓中，与造血干细胞密切相互作用，支持造血干细胞的生长和分化。它们可以抑制T细胞、B细胞、自然杀伤细胞和树突状细胞等多种免疫细胞的增殖或功能。近年来，间充质干细胞移植研究取得了重大进展。实验和临床数据表明，该疗法已成为一种有希望的策略，严重和难治性系统性红斑狼疮。
Mesenchymal stem cells are a rare subset of stem cells residing in the bone marrow where they closely interact with hematopoietic stem cells and support their growth and differentiation. They can suppress proliferation or functions of many immune cells such as T cells, B cells, natural killer cells and dendritic cells. Recently, a substantial progress has been made in the field of mesenchymal stem cell transplantation. Experimental and clinical data suggest that this therapy has been a promising strategy for severe and refractory systemic lupus erythematosus.