Thymosin stimulates secretion of luteinizing hormone-releasing factor.
Thymosin stimulates secretion of luteinizing hormone-releasing factor.
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DOI：
10.1126/science.7027442
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发表时间：
1981-11
期刊：
影响因子：
56.9
通讯作者：
R. Rebar;A. Miyake;T. Low;A. Goldstein
中科院分区：
文献类型：
--
作者：
R. Rebar;A. Miyake;T. Low;A. Goldstein
部分纯化的胸腺素馏分5和它的合成肽成分之一，胸腺素β 4，但不是胸腺素α 1，刺激分泌促黄体生成素-释放因子从灌流内侧基底下丘脑随机循环雌性大鼠。此外，促黄体生成素从垂体中释放，并与下丘脑顺序灌流。没有释放促黄体激素的反应胸腺素观察到垂体灌流单独。这些数据提供了内分泌胸腺对下丘脑的直接影响的第一个证据，并表明胸腺肽在生殖功能中的潜在重要作用。
Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin beta 4, but not thymosin alpha 1, stimulated secretion of luteinizing hormone--releasing factor from superfused medial basal hypothalami from random cycling female rats. In addition, luteinizing hormone was released from pituitary glands superfused in sequence with hypothalami. No release of luteinizing hormone in response to thymosin was observed from pituitaries superfused alone. These data provide the first evidence of a direct effect of the endocrine thymus on the hypothalamus and suggest a potentially important role for thymic peptides in reproductive function.