Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan
Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan
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DOI：
10.1186/s12902-019-0481-1
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发表时间：
2020-01-06
影响因子：
2.7
通讯作者：
Kokaze, Akatsuki
中科院分区：
文献类型：
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作者：
Shirasawa, Takako;Ochiai, Hirotaka;Kokaze, Akatsuki
研究背景多项研究表明，正常体重伴中心性肥胖（NWCO）与心血管疾病的危险因素如高血压、血脂异常和糖尿病有关。然而，NWCO与高尿酸血症的关系尚未得到详细研究。方法我们调查了2013年4月至2014年3月期间接受定期健康检查的40-64岁日本成年人中NWCO与高尿酸血症之间的关系。肥胖定义为体重指数（BMI）≥ 25 kg/m2，中心性肥胖定义为腰高比（WHtR）≥ 0.5。我们根据肥胖和中心性肥胖将参与者分为以下组：正常体重（BMI 18.5-24.9 kg/m2），无（NW; WHtR < 0.5）和（NWCO）中心性肥胖，以及肥胖无（OB）和（OBCO）中心性肥胖。高尿酸血症定义为男性和女性的血清尿酸分别> 7.0和>= 6.0 mg/dL，或正在接受高尿酸血症的药物治疗。酒精摄入分为有（每日和偶尔摄入）和无（无酒精摄入）。采用逻辑回归模型计算高尿酸血症的比值比（OR）和95%置信区间（CI）。我们分析了来自96，863名参与者（69，241名男性和27，622名女性）的数据。高尿酸血症的患病率在男性和女性分别为21.4%和11.0%，在NWCO参与者中分别为15.6%和30.0%。无论性别如何，与NW相比，OBCO中高尿酸血症的校正OR显著增加（男性：OR，2.12; 95%CI; 2.03-2.21;女性：OR，3.54; 95%CI，3.21-3.90），且与NW相比，NWCO中有统计学意义（男性：OR，1.44; 95%CI，1.36-1.52;女性：OR，1.41; 95%CI，1.27-1.57）。无论饮酒与否，结果都相似。结论我们发现NWCO和OBCO与日本中年男性和女性的高尿酸血症有关。对于体重正常但有向心性肥胖的日本中年人，应结合BMI和WHtR进行筛查，并接受如何预防高尿酸血症的教育。
Background Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. Methods We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40-64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) >= 25 kg/m(2) and central obesity was determined as a waist-to-height ratio (WHtR) >= 0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5-24.9 kg/m(2)) without (NW; WHtR < 0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid > 7.0 and >= 6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model. Results We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4 and 11.0%, and of participants with NWCO respectively 15.6 and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03-2.21; women: OR, 3.54; 95%CI, 3.21-3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36-1.52; women: OR, 1.41; 95%CI, 1.27-1.57). The results were similar regardless of alcohol consumption. Conclusions We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.