OCCULT THYROID PATHOLOGY IN THE YOUNG-ADULT - AN AUTOPSY STUDY OF 138 PATIENTS WITHOUT CLINICAL THYROID-DISEASE
OCCULT THYROID PATHOLOGY IN THE YOUNG-ADULT - AN AUTOPSY STUDY OF 138 PATIENTS WITHOUT CLINICAL THYROID-DISEASE
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DOI：
10.1016/s0046-8177(88)80175-8
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发表时间：
1988-06-01
期刊：
影响因子：
3.3
通讯作者：
HANSON, GA
中科院分区：
文献类型：
--
作者：
KOMOROWSKI, RA;HANSON, GA
对138例年龄在20 ~ 40岁之间，无甲状腺疾病临床或实验室证据的成人尸体解剖的甲状腺，以2 mm的间隔连续切片，显微镜下检查隐匿性甲状腺疾病和解剖变异。隐匿性乳头状癌见于3%的腺体，沿着有一例髓样癌。年轻人中隐匿性甲状腺癌的患病率明显低于文献报道的40岁以上人群（P <0.001）。腺体表现出许多其他形态学变化的重要性外科病理学家。62%的甲状腺包膜不完整。14%的甲状腺滤泡位于包膜内，88%的甲状腺滤泡或结节位于腺体外的甲状腺周围结缔组织内。7%的病例在甲状腺周围带状肌中发现了甲状腺滤泡，这些肌附着在锥体叶上。还观察到一些其他不太常见的解剖变异。
Thyroid glands from autopsies on 138 adults, ages 20 to 40 years, with no known clinical or laboratory evidence of thyroid disease, were serially sectioned at 2 mm intervals and microscopically examined for occult thyroid disease and anatomic variations. Occult papillary carcinoma was found in 3% of the glands, along with a single case of medullary carcinoma. The prevalence of occult thyroid carcinoma in this group of young adults is significantly less than that reported in the literature in people over forty (P < .001). The glands demonstrated a number of other morphologic changes of importance to surgical pathologists. The thyroid capsule was incomplete in 62% of the glands. Thyroid follicles were found in the capsule in 14% of cases and thyroid follicles or nodules were outside the gland in perithyroid connective tissue in 88% of cases. Thyroid follicles were identified in 7% of cases in perithyroid strap muscles attached to the pyramidal lobe. A number of other, less common anatomic variations were also seen.