Induced Pluripotent Stem Cell-Derived Neural Stem Cell Therapy Enhances Recovery in an Ischemic Stroke Pig Model.-猫眼课题宝

诱导的多能干细胞衍生的神经干细胞疗法可增强缺血性中风猪模型中的恢复。

DOI：

10.1038/s41598-017-10406-x

发表时间：

2017-08-30

期刊：

Scientific reports

影响因子：

4.6

通讯作者：

中科院分区：

综合性期刊3区

文献类型：

作者：

Baker EW;Platt SR;Lau VW;Grace HE;Holmes SP;Wang L;Duberstein KJ;Howerth EW;Kinder HA;Stice SL;Hess DC;Mao H;West FD

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577218/

Induced pluripotent stem cell-derived neural stem cells (iNSCs) have significant potential as an autologous, multifunctional cell therapy for stroke, which is the primary cause of long term disability in the United States and the second leading cause of death worldwide. Here we show that iNSC transplantation improves recovery through neuroprotective, regenerative, and cell replacement mechanisms in a novel ischemic pig stroke model. Longitudinal multiparametric magnetic resonance imaging (MRI) following iNSC therapy demonstrated reduced changes in white matter integrity, cerebral blood perfusion, and brain metabolism in the infarcted tissue. The observed tissue level recovery strongly correlated with decreased immune response, enhanced neuronal protection, and increased neurogenesis. iNSCs differentiated into neurons and oligodendrocytes with indication of long term integration. The robust recovery response to iNSC therapy in a translational pig stroke model with increased predictive potential strongly supports that iNSCs may be the critically needed therapeutic for human stroke patients.