Fat preload delays gastric emptying: reversal by cisapride.
Fat preload delays gastric emptying: reversal by cisapride.
复制标题
脂肪预负荷延迟胃排空：西沙必利逆转。
DOI：
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发表时间：
1990
影响因子：
3.4
通讯作者：
G. Mittelbach
中科院分区：
文献类型：
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作者：
G. Stacher;H. Bergmann;G. Gaupmann;C. Schneider;A. Kugi;J. Höbart;A. Binder;G. Mittelbach
1. 含有脂肪的食物消化得更慢。2. 本研究调查了与水预负荷相比，胃内脂肪预负荷是否会影响半固体食物的胃排空和心房运动活动，以及西沙必利是否会逆转这种影响。3. 12名健康受试者分别在三种条件下进行研究：(A)预灌50 ml水；(B)和(C)，预加50ml奶油（20g脂肪）。预加载后，受试者侧躺20分钟。之后，以随机双盲方式静脉注射(A)和(B)条件下的安慰剂和(C)条件下的10mg西沙必利，并摄入半固体放射性标记1150kj膳食。用双头伽马照相机记录胃排空和中枢运动活动50分钟。4. 脂肪预负荷和安慰剂组胃排空明显慢于水预负荷和安慰剂组（P < 0.005）。脂肪预负荷后给予西沙必利消除了脂肪预负荷的延迟效应（P < 0.001）。5. 在记录开始时，脂肪预负荷和安慰剂组的心房收缩幅度高于水预负荷和安慰剂组以及脂肪预负荷和西沙必利组（P < 0.01），此后略有下降，而在其他条件下心房收缩幅度略有增加。收缩的频率和传播速度没有不同的影响。先前摄入脂肪后胃排空延迟，西沙必利可消除这种影响。
1. Meals empty more slowly when they contain fat. 2. This study investigated whether an intragastric fat preload in comparison with a water preload affected gastric emptying of a semisolid meal and antral motor activity, and whether cisapride reversed such effects. 3. Twelve healthy subjects were studied under three conditions each: (A), preload of 50 ml water orally; (B) and (C), preload of 50 ml cream (20 g fat). After preloads, subjects reclined right sided for 20 min. Thereafter, placebo in conditions (A) and (B) and 10 mg cisapride in (C) were administered i.v. in a random double-blind fashion and subjects ingested a semisolid radiolabelled 1150 kJ meal. Gastric emptying and antral motor activity were recorded scintigraphically for 50 min using a dual-headed gamma camera. 4. Gastric emptying was significantly slower (P less than 0.005) after fat preload and placebo than after water preload and placebo. Cisapride administered after fat preload abolished the delaying effect of the fat preload (P less than 0.001). 5. Antral contraction amplitudes after fat preload and placebo were higher (P less than 0.01) than after water preload and placebo as well as fat preload and cisapride at the start of recording and decreased slightly thereafter, whereas slight increases occurred in the other conditions. Frequency and propagation velocity of contractions were not differently affected. 6 Gastric emptying is delayed after prior fat ingestion and this effect is abolished by cisapride.
影响因子：
29.4
作者：
Loo,FD;Palmer,DW;Soergel,KH;Kalbfleisch,JH;Wood,CM
通讯作者：
Wood,CM