COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women.
COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women.
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COVID-19 MRNA疫苗驱动孕妇，哺乳和非怀孕妇女的差异抗体FC功能特征。
DOI：
10.1126/scitranslmed.abi8631
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发表时间：
2021-10-27
影响因子：
17.1
通讯作者：
Alter, Galit
中科院分区：
文献类型：
--
作者：
Atyeo, Caroline;DeRiso, Elizabeth A.;Davis, Christine;Bordt, Evan A.;De Guzman, Rose M.;Shook, Lydia L.;Yonker, Lael M.;Fasano, Alessio;Akinwunmi, Babatunde;Lauffenburger, Douglas A.;Elovitz, Michal A.;Gray, Kathryn J.;Edlow, Andrea G.;Alter, Galit
在整个怀孕期间会发生实质性的免疫变化，以促进母亲对胎儿的耐受性，并允许胎儿生长。然而，额外的局部和全身免疫适应也会发生，使母体免疫系统在怀孕期间和出生后通过哺乳继续保护二联体免受病原体的侵害。这种耐受性和免疫力的微妙平衡，加上生理和激素的变化，导致怀孕期间对特定感染的易感性增加，包括更严重的2019冠状病毒病（COVID-19）。这些变化是否也使孕妇对疫苗接种的反应降低，或诱导免疫应答改变，仍不完全清楚。为了全面定义妊娠期和哺乳期疫苗反应的潜在变化，我们深入分析了一组妊娠期和哺乳期妇女以及年龄匹配的非妊娠对照组的体液疫苗反应。疫苗特异性滴度在孕妇、哺乳期妇女和非孕妇对照组之间具有可比性。然而，与非孕妇相比，在第一次接种疫苗后，孕妇和哺乳期妇女的Fc受体（FcR）结合和抗体效应功能均被延迟动力学诱导，在第二次接种后恢复正常。抗体增强导致母乳中fcr结合滴度高。这些数据表明，怀孕促进了对产生高度炎症抗体的抵抗力，并表明在这一脆弱人群中，迫切需要遵循主要-增强时间表，以确保获得完全免疫。与非孕妇相比，孕妇和哺乳期妇女对mRNA-1273和BNT162b2疫苗产生不同的抗体Fc谱。
Substantial immunological changes occur throughout pregnancy to promote tolerization of the mother to the fetus and allow fetal growth. However, additional local and systemic immunological adaptations also occur, allowing the maternal immune system to continue to protect the dyad against pathogens both during pregnancy and after birth through lactation. This fine balance of tolerance and immunity, along with physiological and hormonal changes, contribute to increased susceptibility to particular infections in pregnancy, including more severe coronavirus disease 2019 (COVID-19). Whether these changes also make pregnant women less responsive to vaccination or induce altered immune responses to vaccination remains incompletely understood. To holistically define potential changes in vaccine response during pregnancy and lactation, we deeply profiled the humoral vaccine response in a group of pregnant and lactating women and non-pregnant age-matched controls. Vaccine-specific titers were comparable between pregnant women, lactating women, and non-pregnant controls. However, Fc receptor (FcR)-binding and antibody effector functions were induced with delayed kinetics in both pregnant and lactating women compared to non-pregnant women after the first vaccine dose, which normalized after the second dose. Antibody boosting resulted in high FcR-binding titers in breastmilk. These data suggest that pregnancy promotes resistance to generating highly inflammatory antibodies and indicates that there is a critical need to follow prime-boost timelines in this vulnerable population to ensure full immunity is attained. Pregnant and lactating women develop distinct antibody Fc profiles in response to the mRNA-1273 and BNT162b2 vaccines compared to non-pregnant women.
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DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
2.2
作者：
Karsten, Christina B.;Mehta, Nickita;Alter, Galit
通讯作者：
Alter, Galit
影响因子：
33.9
作者：
Havers, Fiona P.;Moro, Pedro L.;Bernstein, Henry
通讯作者：
Bernstein, Henry
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
13.8
作者：
Edlow AG;Li JZ;Collier AY;Atyeo C;James KE;Boatin AA;Gray KJ;Bordt EA;Shook LL;Yonker LM;Fasano A;Diouf K;Croul N;Devane S;Yockey LJ;Lima R;Shui J;Matute JD;Lerou PH;Akinwunmi BO;Schmidt A;Feldman J;Hauser BM;Caradonna TM;De la Flor D;D'Avino P;Regan J;Corry H;Coxen K;Fajnzylber J;Pepin D;Seaman MS;Barouch DH;Walker BD;Yu XG;Kaimal AJ;Roberts DJ;Alter G
通讯作者：
Alter G