Cilia, Wnt signaling, and the cytoskeleton.
Cilia, Wnt signaling, and the cytoskeleton.
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DOI：
10.1186/2046-2530-1-7
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发表时间：
2012-05-02
期刊：
影响因子：
--
通讯作者：
Kelley MW
中科院分区：
文献类型：
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作者：
May-Simera HL;Kelley MW
初级纤毛最近被强调为发育和疾病的关键调节因子。本文主要介绍纤毛相关蛋白在发育信号系统中的广泛作用。特别要考虑的是位于纤毛底部的基底体区域的重要性，因为它是许多信号通路的焦点，也是微管组织中心。由于纤毛实际上是细胞骨架的微管延伸，研究纤毛和细胞骨架之间的联系可以更好地了解信号和细胞功能。在与初级纤毛相关的许多信号通路中，与细胞骨架和细胞骨架重排相关的研究最广泛的是典型和非典型的Wnt通路。目前出现的一个关键概念是，传统上与纤毛相关的蛋白质可能在细胞过程的其他方面发挥额外的作用。在许多情况下，这种突起的破坏表现在纤毛水平。虽然纤毛和纤毛相关蛋白在信号通路中的作用目前正在被揭开，但越来越多的证据支持这样的观点，即纤毛蛋白不仅是调节Wnt信号所必需的，而且是Wnt信号的下游效应者。本文综述了纤毛和基体蛋白参与Wnt信号通路的最新研究进展。
Primary cilia have recently been highlighted as key regulators in development and disease. This review focuses on current work demonstrating the broad role of cilia-related proteins in developmental signaling systems. Of particular consideration is the importance of the basal body region, located at the base of the cilium, in its role as a focal point for many signaling pathways and as a microtubule organizing center. As the cilium is effectively a microtubular extension of the cytoskeleton, investigating connections between the cilium and the cytoskeleton provides greater insight into signaling and cell function. Of the many signaling pathways associated with primary cilia, the most extensively studied in association with the cytoskeleton and cytoskeletal rearrangements are both canonical and non-canonical Wnt pathways. One of the key concepts currently emerging is a possible additional role for the traditionally 'cilia-related' proteins in other aspects of cellular processes. In many cases, disruption of such processes manifests at the level of the cilium. While the involvement of cilia and cilia-related proteins in signaling pathways is currently being unraveled, there is a growing body of evidence to support the notion that ciliary proteins are required not only for regulation of Wnt signaling, but also as downstream effectors of Wnt signaling. This review summarizes recent advances in our understanding of the involvement of cilia and basal body proteins in Wnt signaling pathways.