Expression level of hepatoma-derived growth factor correlates with tumor recurrence of esophageal carcinoma
Expression level of hepatoma-derived growth factor correlates with tumor recurrence of esophageal carcinoma
复制标题
DOI：
10.1245/s10434-007-9369-9
复制
发表时间：
2007-07-01
影响因子：
3.7
通讯作者：
Monden, Morito
中科院分区：
文献类型：
--
作者：
Yamamoto, Shinji;Tomita, Yasuhiko;Monden, Morito
背景：肝癌衍生生长因子(HDGF)被认为在肿瘤的发生发展中起重要作用。方法：采用免疫组织化学方法检测111例食管癌患者(男101例，女10例)年龄38~82岁(中位数61岁)组织中HDGF的表达情况。其中90%的肿瘤细胞胞核和胞浆中的HDGF表达水平大于或等于内皮细胞中的HDGF表达水平，称为HDGF表达水平1，其余为HDGF表达水平0。HDGF的表达与其他临床病理因素无关。与表达水平为0的患者相比，表达水平为1的患者的无病生存率和总存活率更低(P<；0.05)。HDGF表达是早期(PT1-2)患者的独立预后因素，而晚期(PT3-4)患者则不是。结论：HDGF表达水平是EC的预后因素。
Background: Hepatoma-derived growth factor (HDGF) is thought to play an important role in the development and progression of carcinomas. In the present study, association of HDGF expression with recurrence and prognosis of esophageal carcinoma (EC) was examined.Methods: HDGF expression in 111 patients with EC (101 men and 10 women) with ages ranging from 38 to 82 (median, 61) years was analyzed by immunohistochemistry. Samples in which > 90% of tumor cells exhibited nuclear and cytoplasmic HDGF immunoreactivity at levels greater than or equal to what is observed in the endothelial cells were regarded as HDGF expression level 1, and others as HDGF expression level 0.Results: Thirty-seven of 111 patients showed level 1 HDGF expression. There was no correlation between HDGF expression and other clinicopathologic factors. Patients with level 1 expression showed poorer disease-free and overall survival (P < .05 for both) compared with those with level 0 expression. HDGF expression was an independent prognostic factor for patients with early (pT1-2) stage of the disease, but not for those with advanced (pT3-4) stage.Conclusions: HDGF expression level was shown to be a prognostic factor for EC.