Adipocyte Fatty Acid Binding Protein Levels Relate to Inflammation and Fibrosis in Nonalcoholic Fatty Liver Disease
Adipocyte Fatty Acid Binding Protein Levels Relate to Inflammation and Fibrosis in Nonalcoholic Fatty Liver Disease
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DOI：
10.1002/hep.22896
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发表时间：
2009-06-01
期刊：
影响因子：
13.5
通讯作者：
George, Jacob
中科院分区：
文献类型：
--
作者：
Milner, Kerry-Lee;van der Poorten, David;George, Jacob
几种循环细胞因子随着肥胖而增加，并且可能与内脏脂肪的影响结合联合收割机，从而在非酒精性脂肪性肝病（NAFLD）中产生胰岛素抵抗、炎症和纤维化。在NAFLD中存在关于三种最近认识到的组织来源的细胞因子的信息很少，这些细胞因子都是脂质结合的并且参与炎症，即脂肪细胞脂肪酸结合蛋白（AFABP）、脂质运载蛋白-2和视黄醇结合蛋白4（RBP 4）。我们在100名NAFLD受试者和129名匹配的对照者中研究了这三种肽与肝脂肪变性、炎症和纤维化以及肥胖、胰岛素抵抗和血脂异常指数的相关性。与对照组相比，NAFLD患者AFABP和脂质运载蛋白-2水平显著升高（AFABP，33.5 +/- 14.4 vs 23.1 +/- 12.1 ng/mL [P < 0.001];脂质运载蛋白-2，63.2 +/- 26 vs 48.6 +/- 20 ng/mL [P < 0.001]），且与肥胖指数相关。AFABP与皮下脂肪指数相关，而非内脏脂肪指数。AFABP单独区分脂肪性肝炎和单纯脂肪变性（P = 0.02）。AFABP升高独立预测炎症和纤维化的增加，即使考虑胰岛素抵抗和内脏脂肪;这适用于小叶炎症和气球样变（比值比1.4，置信区间1.0-1.8）和纤维化分期（比值比1.3，置信区间1.0-1.7）（P
Several circulating cytokines are increased with obesity and may combine with the influence of visceral fat to generate insulin resistance, inflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD). Little information exists in NAFLD about three recently recognized tissue-derived cytokines that are all lipid-binding and involved in inflammation, namely adipocyte fatty acid-binding protein (AFABP), lipocalin-2, and retinol-binding protein 4 (RBP4). We examined the association of these three peptides with hepatic steatosis, inflammation, and fibrosis plus indices of adiposity, insulin resistance, and dyslipidaemia in 100 subjects with NAFLD and 129 matched controls. Levels of AFABP and lipocalin-2, but not RBP4, were significantly elevated in NAFLD versus control (AFABP, 33.5 +/- 14.4 versus 23.1 +/- 12.1 ng/mL [P < 0.001]; lipocalin-2, 63.2 +/- 26 versus 48.6 +/- 20 ng/mL [P < 0.001]) and correlated with indices of adiposity. AFABP correlated with indices of subcutaneous rather than visceral fat. AFABP alone distinguished steatohepatitis from simple steatosis (P = 0.02). Elevated AFABP independently predicted increasing inflammation and fibrosis, even when insulin resistance and visceral fat were considered; this applied to lobular inflammation and ballooning (odds ratio 1.4, confidence interval 1.0-1.8) and fibrosis stage (odds ratio 1.3, confidence interval 1.0-1.7) (P