BIOLOGICAL MONITORING OF CADMIUM EXPOSURE - RELIABILITY OF SPOT URINE SAMPLES
BIOLOGICAL MONITORING OF CADMIUM EXPOSURE - RELIABILITY OF SPOT URINE SAMPLES
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DOI：
10.1007/bf00383246
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发表时间：
1994-03-01
影响因子：
3
通讯作者：
SECONDIN, L
中科院分区：
文献类型：
--
作者：
TREVISAN, A;NICOLETTO, G;SECONDIN, L
现场尿样浓缩稀释是工业外源性物质生物监测的一个缺点。为确定现场尿镉测定值的调整是否适当，对25名从事珠宝首饰生产的电焊工进行了连续3周、每周1次的3次尿镉采样（共75个样品）。镉，肌酐，比重，总尿溶质，尿量和尿流率进行了测量，在12小时的收集和现场取样后立即采取。尿肌酐和尿总溶质与尿流率呈高度负相关（r = -0.858和r = -0.768）。尿镉呈类似趋势，但相关性不显著（r = -0.145）。与未校正的尿量（r =-0.732）和尿流率（r = 0.738）相比，尿镉校正后的尿镉与定时尿镉的相关性增加（r = -0.808）和尿流率（r = 0.821）。点样值的肌酐调整也适用于广泛的尿液浓度范围;丢弃过度稀释或浓缩的尿液，未调整或比重调整值的尿液样本相关性得到改善，而肌酐调整值未观察到变化。
Concentration-dilution of spot urine samples is a shortcoming of the biological monitoring of industrial xenobiotics. To ascertain whether the adjustment of urinary cadmium measured in spot samples is appropriate, urine samples were taken three times, once a week for 3 successive weeks, from 25 welders employed in the manufacture of jewellery (total 75 samples). Cadmium, creatinine, specific gravity, total urinary solutes, urinary volume and urinary flow rate were measured in 12-h collections and in spot samples taken immediately afterwards. Creatinine and total urinary solutes showed high inverse correlation with urinary flow rate (r = -0.858 and r = -0.768 respectively). Urinary cadmium displayed a similar trend but the correlation was not significant (r = -0.145). Creatinine adjustment of urinary cadmium values in spot samples increased the correlation with the same index in timed samples adjusted for urinary volume (r = -0.808) or urinary flow rate (r = 0.821) compared with non-adjustment (r = 0.732 and r = 0.738, respectively). Creatinine adjustment of spot sample values is also suitable for a wide range of urinary concentrations; discarding excessively diluted or concentrated urines, correlation of urine samples improved for non-adjusted or specific gravity-adjusted values, whereas no changes were observed for creatinine-adjusted values.