Secondary Particle Interactions in a Compton Camera Designed for in vivo Range Verification of Proton Therapy.
Secondary Particle Interactions in a Compton Camera Designed for in vivo Range Verification of Proton Therapy.
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DOI：
10.1109/trpms.2020.3030166
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发表时间：
2021-05
影响因子：
4.4
通讯作者：
Beddar S
中科院分区：
文献类型：
--
作者：
Panthi R;Maggi P;Peterson S;Mackin D;Polf J;Beddar S
本研究的目的是确定康普顿相机（CC）在临床质子束输送过程中二次粒子相互作用的类型、比例和能量。应用Geant4软件（10.4版）模拟了70 - 200 MeV的临床质子束入射水影的传输。模拟包括一个类似于北极星J3 CC配置的CC，用于成像质子束照射过程中发出的提示伽马（pg），目的是在体内范围验证。对每个CC检测器模块中二次粒子的相互作用位置和能量进行了评分。在150-MeV质子束中，每108个质子中有156,688个（575个）次级粒子到达相机模组，主要由伽马射线（46.31%）、中子（41.37%）和电子（8.88%）组成，其中79.37%的次级粒子与模组相互作用。使用CCs进行质子范围验证的策略应该包括减少大中子背景和低能非pg辐射的方法。本研究中各模块交互类型的比例可以为背景抑制提供有用的信息。
The purpose of this study was to determine the types, proportions, and energies of secondary particle interactions in a Compton camera (CC) during the delivery of clinical proton beams. The delivery of clinical proton pencil beams ranging from 70 to 200 MeV incident on a water phantom was simulated using Geant4 software (version 10.4). The simulation included a CC similar to the configuration of a Polaris J3 CC designed to image prompt gammas (PGs) emitted during proton beam irradiation for the purpose of in vivo range verification. The interaction positions and energies of secondary particles in each CC detector module were scored. For a 150-MeV proton beam, a total of 156,688(575) secondary particles per 108 protons, primarily composed of gamma rays (46.31%), neutrons (41.37%), and electrons (8.88%), were found to reach the camera modules, and 79.37% of these particles interacted with the modules. Strategies for using CCs for proton range verification should include methods of reducing the large neutron backgrounds and low-energy non-PG radiation. The proportions of interaction types by module from this study may provide information useful for background suppression.