Erectile dysfunction as a predictor of the metabolic syndrome in aging men: Results from the Massachusetts Male Aging Study
Erectile dysfunction as a predictor of the metabolic syndrome in aging men: Results from the Massachusetts Male Aging Study
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DOI：
10.1016/s0022-5347(06)00503-9
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发表时间：
2006-07-01
影响因子：
6.6
通讯作者：
McKinlay, John B.
中科院分区：
文献类型：
--
作者：
Kupelian, Varant;Shabsigh, Ridwan;McKinlay, John B.
目的：以向心性肥胖、胰岛素调节异常、血脂异常和临界性高血压为特征的代谢综合征是心血管疾病的先兆状态。我们确定勃起功能障碍是否是metabolic syndrome.Materials and Methods的预测：数据来自马萨诸塞州男性老龄化研究，一个基于人群的前瞻性队列观察在3个点在大约15年（T-1-1987年至1989年，T-2-1995年至1997年，T-3-2002年至2004年）。代谢综合征的定义采用成人治疗组III指南的修改版。勃起功能障碍和代谢综合征之间的关联进行了评估，使用相对危险度和95%置信区间估计使用Poisson回归models.Results：分析进行了928名男子没有代谢综合征在T，有293名男子与事件代谢综合征，其中56勃起功能障碍在基线。体重指数和存在1或2个构成代谢综合征定义的条件是代谢综合征的最强预测因子。勃起功能障碍与代谢综合征的关系（未校正RR 1.35，95% CI 1.01-1.81）经体重指数修正，体重指数小于25的男性勃起功能障碍的影响更强（调整后的RR 2.09，95% CI 1.09-4.02），在体重指数25或更高的男性中，勃起功能障碍与代谢综合征无相关性结论：勃起功能障碍仅在体重指数小于25的男性中预测代谢综合征。这一发现表明，勃起功能障碍可能为男性提供一个警告信号和早期干预的机会，否则被认为是代谢综合征和随后的心血管疾病的风险较低。
Purpose: The metabolic syndrome, characterized by central obesity, insulin dysregulation, abnormal lipids and borderline hypertension, is a precursor state for cardiovascular disease. We determined whether erectile dysfunction is predictive of the metabolic syndrome.Materials and Methods: Data were obtained from the Massachusetts Male Aging Study, a population based prospective cohort observed at 3 points during approximately 15 years (T-1-1987 to 1989, T-2-1995 to 1997, T-3-2002 to 2004). The metabolic syndrome was defined by using a modification of the Adult Treatment Panel III guidelines. The association between erectile dysfunction and the metabolic syndrome was assessed using relative risks and 95% confidence intervals estimated using Poisson regression models.Results: Analysis was conducted of 928 men without the metabolic syndrome at T, There were 293 men with incident metabolic syndrome, of which 56 had erectile dysfunction at baseline. Body mass index and the presence of 1 or 2 conditions constituting the metabolic syndrome definition were the strongest predictors of the metabolic syndrome. The association of erectile dysfunction with the metabolic syndrome (unadjusted RR 1.35, 95% CI 1.01-1.81) was modified by body mass index, with a stronger effect of erectile dysfunction in men with body mass index less than 25 (adjusted RR 2.09, 95% CI 1.09-4.02), and no erectile dysfunction and metabolic syndrome association in men with body mass index 25 or greater (adjusted RR 1.06, 95% CI 0.76-1.50).Conclusions: Erectile dysfunction was predictive of the metabolic syndrome only in men with body mass index less than 25. This finding suggests that erectile dysfunction may provide a warning sign and an opportunity for early intervention in men otherwise considered at lower risk for the metabolic syndrome and subsequent cardiovascular disease.