Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome
Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome
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FCM 和 GATA1-PCR 诱导后 MRD 是唐氏综合征髓系白血病的重要预后因素
DOI：
10.1038/s41375-021-01157-w
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发表时间：
2021
期刊：
影响因子：
11.4
通讯作者：
Terui Kiminori、Toki Tsutomu、Ito Etsuro、et al.
中科院分区：
文献类型：
--
作者：
Taga Takashi;Terui Kiminori、Toki Tsutomu、Ito Etsuro、et al.
唐氏综合症髓系白血病 (ML-DS) 与化疗的良好反应相关，从而产生良好的结果。然而，迄今为止尚未确定普遍的预后因素。为了明确复发风险高的亚组，日本小儿白血病/淋巴瘤研究组在 AML-D11 试验中探讨了微小残留病 (MRD) 的作用。使用流式细胞术 (FCM-MRD) 和 GATA1 靶向深度测序 (GATA1-MRD) 对诱导治疗后和所有化疗结束时的 MRD 进行前瞻性评估。共有 78 名患者符合资格，其中 76 名患者按形态学分为标准风险 (SR) 组。在SR患者中，诱导后FCM-MRD和GATA1-MRD分别为5/65和7/59患者阳性。 FCM-MRD 阴性人群的三年无事件生存率 (EFS) 和总生存率 (OS) 分别为 95.0% 和 96.7%，阳性人群为 60.0% 和 80.0%。 GATA1-MRD 阴性人群的三年 EFS 和 OS 率均为 98.1%，阳性人群为 57.1% 和 71.4%。 FCM-MRD 与 EFS 关联的调整后风险比为 14.67 (p= 0.01)。初始诱导治疗后通过 FCM 或 GATA1 检测 MRD 是预测 ML-DS 复发的重要预后因素。
Myeloid leukemia of Down syndrome (ML-DS) is associated with good response to chemotherapy, resulting in favorable outcomes. However, no universal prognostic factors have been identified to date. To clarify a subgroup with high risk of relapse, the role of minimal residual disease (MRD) was explored in the AML-D11 trial by the Japanese Pediatric Leukemia/Lymphoma Study Group. MRD was prospectively evaluated at after induction therapy and at the end of all chemotherapy, using flow cytometry (FCM-MRD) andGATA1-targeted deep sequencing (GATA1-MRD). A total of 78 patients were eligible and 76 patients were stratified to the standard risk (SR) group by morphology. In SR patients, FCM-MRD andGATA1-MRD after induction were positive in 5/65 and 7/59 patients, respectively. Three-year event-free survival (EFS) and overall survival (OS) rates were 95.0% and 96.7% in the FCM-MRD-negative population, and 60.0% and 80.0% in the positive population. Three-year EFS and OS rates were both 98.1% in theGATA1-MRD-negative population, and 57.1% and 71.4% in the positive population. Adjusted hazard ratios for associations of FCM-MRD with EFS were 14.67 (p= 0.01). Detection of MRD by either FCM orGATA1after initial induction therapy represents a significant prognostic factor for predicting ML-DS relapse.
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影响因子：
51.1
作者：
Rubnitz, Jeffrey E.;Inaba, Hiroto;Dahl, Gary;Ribeiro, Raul C.;Bowman, W. Paul;Taub, Jeffrey;Pounds, Stanley;Razzouk, Bassem I.;Lacayo, Norman J.;Cao, Xueyuan;Meshinchi, Soheil;Degar, Barbara;Airewele, Gladstone;Raimondi, Susana C.;Onciu, Mihaela;Coustan-Smith, Elaine;Downing, James R.;Leung, Wing;Pui, Ching-Hon;Campana, Dario
通讯作者：
Campana, Dario
影响因子：
20.3
作者：
Xu, G;Nagano, M;Ito, E
通讯作者：
Ito, E
影响因子：
6.5
作者：
Al-Ahmari, Ali;Shah, Niketa;Hitzler, Johann
通讯作者：
Hitzler, Johann
影响因子：
45.3
作者：
Kudo, Kazuko;Kojima, Seiji;Tsukimoto, Ichiro
通讯作者：
Tsukimoto, Ichiro