Correlation between uncinate fasciculus and memory tasks in healthy individual using diffusion tensor tractography
Correlation between uncinate fasciculus and memory tasks in healthy individual using diffusion tensor tractography
复制标题
DOI：
10.1109/embc.2012.6345958
复制
发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Tetsuo Sato;N. Maruyama;T. Hoshida;K. Minato
中科院分区：
文献类型：
--
作者：
Tetsuo Sato;N. Maruyama;T. Hoshida;K. Minato
纤维束成像是一种可以跟踪和显示大脑白色物质的3D神经束的程序。通过分析扩散张量来获得大脑的图像，对扩散张量的识别可以提供大脑的解剖学连接。研究这些连接是理解大脑功能不可或缺的。具体而言，钩束（UF），即人脑中的白色物质，据说与认知功能有关。使用扩散张量成像（DTI）参数计算UF纤维束成像。研究表明，痴呆患者的DTI参数低于健康人。健康人的DTI参数随年龄增长而降低。此外，老年人的WMS-R得分低于年轻人，该得分指示一般记忆、言语记忆和其他认知功能。然而，目前还没有关于DTI参数和记忆功能的整体研究的报道。因此，在本研究中，我们计算了UF的DTI参数与WMS-R评分之间的相关系数。结果表明，纤维方向扩散系数与左侧UF视觉记忆的相关系数最大为-0.226。DTI测量结果与记忆成绩之间的相关性表明了UF与记忆任务侧化功能之间的关系。我们的发现与之前关于左侧FA或右侧UF中的L1与视觉记忆表现之间的相关性的报告相匹配。
Tractography is a procedure that can track and demonstrate the 3D neural tracts of the white matter of the brain. The images of the brain are obtained by analyzing the diffusion tensor, identification of which can provide the anatomical connections of the brain. Studying these connections is integral to the understanding of the brain function. Specifically, the uncinate fasciculus (UF), which is the white matter in the human brain, is said to be related to cognitive function. The UF tractography is calculated using diffusion tensor imaging (DTI) parameter. Studies have shown that the DTI parameter of dementia patients is lower than that of healthy individuals. It is also suggested that the DTI parameter of healthy individuals decreases with age. In addition, the WMS-R score, which is indicative of general memory, verbal memory and other cognitive functions, of the elderly are lower than of the young. However, there is no report yet that has holistically investigated DTI parameter and the memory functions. Thus, in this research, we have calculated the correlation coefficient between the DTI parameter of UF and WMS-R score. Our result shows that the correlation coefficient of diffusivity of the fiber direction and visual memory of a left UF is -0.226 at the maximum. Correlation between DTI measurement and memory performance suggests the relationships between the UF and function in memory tasks lateralization. Our finding matches previous reports on the correlation between FA in the left, or L1 in the right UF, and performance on visual memory.