Expression of RAB27B is up-regulated in senescent human cells
Expression of RAB27B is up-regulated in senescent human cells
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DOI：
10.1016/j.mad.2006.03.001
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发表时间：
2006-07-01
影响因子：
5.3
通讯作者：
Ayusawa, Dai
中科院分区：
文献类型：
--
作者：
Fujii, Michihiko;Kawai, Yoshinori;Ayusawa, Dai
表达耐热性SV40 T抗原的不朽SVts8细胞在T抗原失活后表现出类似衰老的现象。利用cDNA减法杂交技术，发现RAB27B作为RAB GTPase家族的成员，在衰老的SVts8细胞中表达上调。RAB27B的上调依赖于p53基因。在正常人成纤维细胞的复制性衰老中也观察到表达增强。2006爱思唯尔爱尔兰有限公司版权所有。
Immortal SVts8 cells that express thermolabile SV40 T antigen exhibit a senescence-like phenomenon upon inactivation of the T antigen. By using a cDNA subtractive hybridization technique, RAB27B, a member of the RAB GTPase family, was found to be up-regulated in senescent SVts8 cells. The up-regulation of RAB27B depends on the p53 gene. Enhanced expression was also observed in replicative senescence in normal human fibroblasts. (c) 2006 Elsevier Ireland Ltd. All rights reserved.