The effect of exercise in a fasted state on plasma low-density lipoprotein cholesterol concentrations in males and females
The effect of exercise in a fasted state on plasma low-density lipoprotein cholesterol concentrations in males and females
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空腹运动对男性和女性血浆低密度脂蛋白胆固醇浓度的影响
DOI：
10.1113/ep091005
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发表时间：
2023
影响因子：
2.7
通讯作者：
Bradshaw L
中科院分区：
文献类型：
--
作者：
Bradshaw L
心血管疾病（CVD）是全世界死亡的主要原因。体力活动干预措施可以改善几乎所有可改变的 CVD 危险因素，但体力活动对低密度脂蛋白胆固醇 (LDL-C) 的影响尚不确定。这可能是由于缺乏对进行体力活动时的进食状态的研究。本研究的目的是调查空腹运动与进食运动对男性和女性 LDL-C 浓度的影响。将招募 100 名健康参与者，男女平等，年龄在 25 至 60 岁之间，并将接受为期 12 周的家庭运动干预。基线测试后，参与者将被随机分配到空腹运动（禁食 8 小时后运动）或进食运动（摄入 1 g kg−1CHO 后 90-180 分钟运动）组，并在高碳水化合物 (1 g kg−1) 餐前或餐后每周进行 3 次 50 分钟的中等强度运动（例如，乳酸阈值 1 的 95% 心率）。参与者将在第 4 周和第 12 周再次访问实验室，测量身体成分、静息血压、空腹血糖、血脂谱和全身炎症、乳酸阈值和 14 天血糖控制。
Cardiovascular disease (CVD) is the leading cause of death worldwide. Physical activity interventions improve almost all modifiable CVD risk factors, but the effect of physical activity on low density lipoprotein cholesterol (LDL‐C) is uncertain. This may be due to lack of research on the feeding status in which the physical activity is performed. The aim of this study is to investigate the effect of fasted versus fed exercise on LDL‐C concentrations in males and females. One hundred healthy participants, equal males and females, aged between 25 and 60 years will be recruited and will undergo a home‐based 12‐week exercise intervention. After baseline testing, participants will be randomized to a fasted exercise (exercise after an 8‐h fast) or fed exercise (exercise 90–180 min after ingestion of 1 g kg−1CHO) group and will perform 50 min of moderate intensity exercise (e.g., 95% heart rate of lactate threshold 1) three times a week either before or after a high carbohydrate (1 g kg−1) meal. Participants will visit the laboratory again at week 4 and week 12 and measurements will be taken for body composition, resting blood pressure, fasting blood glucose, lipid profiles and systemic inflammation, lactate threshold, and 14‐day blood glucose control.