The effects of hyperlipidemia on implant osseointegration in the mouse femur.
The effects of hyperlipidemia on implant osseointegration in the mouse femur.
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DOI：
10.1563/aaid-joi-d-13-00105
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Aghaloo T
中科院分区：
文献类型：
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作者：
Keuroghlian A;Barroso AD;Kirikian G;Bezouglaia O;Tintut Y;Tetradis S;Moy P;Pirih F;Aghaloo T
高脂肪饮食引起的高脂血症与动脉粥样硬化和骨质疏松等重大疾病的病理生理有关。HF饮食对骨骼有明显的不良影响，包括降低骨密度、体积和强度。他汀类药物，一种降低血清胆固醇水平的药物，对骨代谢有益。由于宿主骨的数量、质量和愈合潜力在种植体骨整合中起着至关重要的作用，我们推测高脂血症可能会对种植体骨整合产生负面影响。在本研究中，我们评估了高脂血症对小鼠种植体骨整合的影响。对动脉粥样硬化易感的C57BL/6J雄性小鼠随机喂食对照饲料或HF饲料。12周后，每只小鼠在股骨近端干骺端植入钛。动物在植入手术后4周或8周被处死。结果表明，HF日粮喂养小鼠显著增加了种植体的损失，降低了骨-种植体界面的形成和强度。这些结果支持了一种假设，即HF饮食会显著损害骨整合，导致种植牙治疗的不良结果。
A high-fat (HF) diet inducing hyperlipidemia has been associated with the pathophysiology of major diseases, such as atherosclerosis and osteoporosis. A HF diet has significant adverse effects on bone, including lower bone density, volume and strength. Statins, drugs that lower serum cholesterol levels have beneficial effects on bone metabolism. Since host’s bone quantity, quality and healing potential play a crucial role in osseointegration of dental implants, we hypothesized that hyperlipidemia may negatively affect implant osseointegration. In the present study, we evaluated the effects of hyperlipidemia on implant osseointegration in mice. Atherosclerosis susceptible C57BL/6J male mice were randomly placed on a control chow or an HF diet. After 12 weeks on the diet, each mouse received a titanium implant in the proximal metaphysis of the femur. The animals were sacrificed at 4 or 8 weeks after the implant surgery. Results showed that the HF diet fed mice had significantly increased implant loss as well as decreased formation and strength of bone-to-implant interface. These results support the hypothesis that an HF diet can significantly compromise osseointegration, causing poor outcome in dental implant therapy.