New waves in dendritic spine actin cytoskeleton: From branches and bundles to rings, from actin binding proteins to post-translational modifications
New waves in dendritic spine actin cytoskeleton: From branches and bundles to rings, from actin binding proteins to post-translational modifications
复制标题
DOI：
10.1016/j.mcn.2017.05.002
复制
发表时间：
2017-10-01
影响因子：
3.5
通讯作者：
Hotulainen, Pirta
中科院分区：
文献类型：
--
作者：
Bertling, Enni;Hotulainen, Pirta
树突棘是神经元树突上富含肌动蛋白的小突起，形成大多数兴奋性突触的突触后部分。突触数量或强度的变化是学习背后的生理机制。树突棘的生长和成熟以及活动诱导的形态学变化都是基于肌动蛋白细胞骨架的变化。在这篇综述中，我们将讨论树突棘的形成和成熟，以及在突触强化的肌动蛋白细胞骨架的调节。关于脊柱的形成，我们将集中在脊柱的启动，这在文献中得到较少的关注。我们还将研究最近发现的调节肌动蛋白细胞骨架通过翻译后修饰的肌动蛋白单体，除了通过肌动蛋白结合蛋白的肌动蛋白的常规调节。(C)2017爱思唯尔公司All rights reserved.
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses. Changes in the number or strength of synapses are physiological mechanisms behind learning. The growth and maturation of dendritic spines and the activity-induced changes to their morphology are all based on changes to the actin cytoskeleton. In this review, we will discuss the regulation of the actin cytoskeleton in dendritic spine formation and maturation, as well as in synaptic strengthening. Concerning spine formation, we will focus on spine initiation, which has received less attention in the literature. We will also examine the recently revealed regulation of the actin cytoskeleton through post-translational modifications of actin monomers, in addition to the conventional regulation of actin via actin-binding proteins. (C) 2017 Elsevier Inc. All rights reserved.