Sample size in studies on diagnostic accuracy in ophthalmology: a literature survey
Sample size in studies on diagnostic accuracy in ophthalmology: a literature survey
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DOI：
10.1136/bjo.2006.113290
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发表时间：
2007-07-01
影响因子：
4.1
通讯作者：
Azuara-Blanco, Augusto
中科院分区：
文献类型：
--
作者：
Bochmann, Frank;Johnson, Zoe;Azuara-Blanco, Augusto
目的：评价用于眼科诊断准确性研究的样本量。设计和来源：2005年发表的一份调查文献。方法：从已发表的文献中提取报告样本量计算频次和样本量。由两名独立的调查人员对影响最大的五种眼科主要临床期刊（《眼科学与视觉科学调查》、《眼科学》、《眼科学档案》、《美国眼科学杂志》和《英国眼科学杂志》）进行了人工检索。结果：共纳入文献1698篇，其中诊断准确性研究40篇。一项研究报告说，在开始研究之前计算了样本量。另一项研究报告了在没有计算的情况下考虑样本量。所有诊断研究的平均（SD）样本量为172.6（218.9）。目标疾病的中位患病率为50.5%。结论：只有少数研究在其方法中考虑了样本量。诊断准确性研究中样本量不足可能导致对测试准确性的误导性估计。对诊断研究的设计和报告的现行标准进行改进是必要的。
Aim: To assess the sample sizes used in studies on diagnostic accuracy in ophthalmology.Design and sources: A survey literature published in 2005.Methods: The frequency of reporting calculations of sample sizes and the samples' sizes were extracted from the published literature. A manual search of five leading clinical journals in ophthalmology with the highest impact ( Investigative Ophthalmology and Visual Science, Ophthalmology, Archives of Ophthalmology, American Journal of Ophthalmology and British Journal of Ophthalmology) was conducted by two independent investigators.Results: A total of 1698 articles were identified, of which 40 studies were on diagnostic accuracy. One study reported that sample size was calculated before initiating the study. Another study reported consideration of sample size without calculation. The mean ( SD) sample size of all diagnostic studies was 172.6 ( 218.9). The median prevalence of the target condition was 50.5%.Conclusion: Only a few studies consider sample size in their methods. Inadequate sample sizes in diagnostic accuracy studies may result in misleading estimates of test accuracy. An improvement over the current standards on the design and reporting of diagnostic studies is warranted.