ASYMMETRIC-SYNTHESIS OF FR165914 - A NOVEL BETA(3)-ADRENERGIC AGONIST WITH A BENZOCYCLOHEPTENE STRUCTURE
ASYMMETRIC-SYNTHESIS OF FR165914 - A NOVEL BETA(3)-ADRENERGIC AGONIST WITH A BENZOCYCLOHEPTENE STRUCTURE
复制标题
DOI：
10.1016/0960-894x(95)00483-a
复制
发表时间：
1995-12-07
影响因子：
2.7
通讯作者：
SAKANE, K
中科院分区：
文献类型：
--
作者：
HATTORI, K;NAGANO, M;SAKANE, K
描述了一种新型β(3)-肾上腺素能激动剂FR165194的不对称合成。关键步骤包括通过由-甲基苄胺制备的手性亚胺的立体选择性还原制备光学活性胺和通过Sharpless不对称二羟基化合成手性环氧化物。
The asymmetric synthesis of a novel beta(3)-adrenergic agonist FR165194 is described. The critical steps involve preparation of an optically active amine via stereoselective reduction of a chiral imine prepared from alpha-methylbenzylamine and synthesis of a chiral epoxide via the Sharpless asymmetric dihydroxylation.