THIGH MAGNETIC RESONANCE IMAGING FOR THE EVALUATION OF DISEASE ACTIVITY IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES FOLLOWED IN A SINGLE CENTER
THIGH MAGNETIC RESONANCE IMAGING FOR THE EVALUATION OF DISEASE ACTIVITY IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES FOLLOWED IN A SINGLE CENTER
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DOI：
10.1002/mus.25099
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发表时间：
2016-10-01
期刊：
影响因子：
3.4
通讯作者：
Neri, Rossella
中科院分区：
文献类型：
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作者：
Barsotti, Simone;Zampa, Virna;Neri, Rossella
简介：对于特发性炎症性肌病 (IIM) 患者，磁共振成像 (MRI) 已被提议作为诊断和随访的有用工具。它可以识别肌肉炎症（水肿）和脂肪浸润，以评估疾病活动和损害。关于 MRI 在评估大量成年 IIM 患者中的作用的信息很少。方法：51 名患者接受了大腿肌肉 MRI、实验室检查和临床评估，包括肌炎活动性医师总体评估 (PGA) 和徒手肌肉测试 8 (MMT8)。结果：肌肉水肿与肌酸激酶值 (P = 0.017) 和 PGA (P < 0.001) 显着相关。当排除肌肉脂肪浸润患者时，观察到水肿与 MMT8 值之间存在显着相关性 (P = 0.025)。就临床诊断而言，MRI的敏感性为92.3%，特异性为83.3%。结论：MRI 似乎可以提供补充临床和生化检查的额外信息。
Introduction: In patients with idiopathic inflammatory myopathies (IIM), magnetic resonance imaging (MRI) has been proposed as a useful tool for diagnosis and follow-up. It may identify muscle inflammation (edema) and fatty infiltration for evaluation of disease activity and damage. Little information is available on the role of MRI in assessment of large cohorts of adult patients with IIM. Methods: Fifty-one patients underwent MRI of the thigh muscles, laboratory tests, and clinical evaluation, including Physician Global Assessment (PGA) of myositis activity and the Manual Muscle Test 8 (MMT8). Results: Muscle edema correlated significantly with creatine kinase values (P = 0.017) and PGA (P < 0.001). A significant correlation between edema and MMT8 values (P = 0.025) was observed when patients with muscle fatty infiltration were excluded. With respect to clinical diagnosis, the sensitivity of MRI was 92.3%, and specificity was 83.3%. Conclusions: MRI appears to provide additional information that complements clinical and biochemical examinations.