Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion
Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion
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DOI：
10.1016/j.autneu.2004.11.012
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发表时间：
2005-06-15
影响因子：
2.7
通讯作者：
Nomura, Y
中科院分区：
文献类型：
--
作者：
Hosoi, T;Okuma, Y;Nomura, Y
迷走神经传入被认为是将外周免疫信号传递到大脑的重要组成部分。然而，有不一致的证据表明，横隔下迷走神经切断术不能抑制外周应用脂多糖(LPS)所引起的大脑介导的行为和神经效应。脂多糖通过Toll样受体4(TLR4)触发先天免疫细胞。在本研究中，我们发现TLR4mRNA和蛋白在大鼠结状神经节中有表达。因此，提示内毒素可激活迷走神经节水平的传入神经，该神经节位于迷走神经的横隔膜下水平。本研究结果为内毒素诱导迷走神经传入神经激活的新途径提供了依据。(C)2005 Elsevier B.V.保留所有权利。
The afferent vagus nerve has been suggested to be an important component for transmitting peripheral immune signals to the brain. However, there is inconsistent evidence showing that subdiaphragmatic vagotomy did not inhibit the brain mediated behavioral and neural effects induced by the peripheral application of lipopolysaccharide (LPS). LPS triggers innate immune cells through Toll-like receptor 4 (TLR4). In the present study, we found that TLR4 mRNA and protein was expressed in the rat nodose ganglion. Thus, it is suggested that LPS could activate afferent vagus nerve at the level of nodose ganglion, which exists centrally from the subdiaphragmatic level of vagus nerve. The results could provide evidence for the novel pathway of LPS-induced afferent vagus nerve activation. (c) 2005 Elsevier B.V. All rights reserved.