Growth factor control of bone mass.
Growth factor control of bone mass.
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DOI：
10.1002/jcb.22322
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发表时间：
2009-11-01
影响因子：
4
通讯作者：
Canalis, Ernesto
中科院分区：
文献类型：
--
作者：
Canalis, Ernesto
骨形成是由成骨细胞的数量和功能决定的。细胞数量由调节前成骨细胞复制和分化的因子和调节成骨细胞死亡的因子控制。细胞功能由作用于成熟成骨细胞的信号控制。血小板衍生因子和成纤维细胞生长因子是骨细胞有丝分裂原。骨形态发生蛋白（BMP）和Wnt诱导间充质细胞向成骨细胞分化，胰岛素样生长因子（IGF）-I刺激成熟成骨细胞的功能并防止其死亡。BMP、Wnt和IGF-I的活性由细胞外拮抗剂或结合蛋白调节。生长因子合成和活性的变化可能在选定形式的骨质疏松症的发病机制中起作用，并且细胞外拮抗剂的表达或结合的改变可能与骨量的变化相关。目前用于骨质疏松症的骨合成代谢疗法的方法包括施用生长因子，如IGF-I，或中和拮抗剂。理想情况下，合成代谢剂的靶向应该特异于骨，以排除非骨骼的不必要的副作用。需要临床试验来确定新型合成代谢药物治疗骨质疏松症的长期有效性和安全性。
Bone formation is determined by the number and function of osteoblasts. Cell number is governed by factors that regulate the replication and differentiation of pre-osteoblasts and factors that regulate osteoblastic cell death. Cell function is controlled by signals acting on the mature osteoblast. Platelet derived and fibroblast growth factors are bone cell mitogens. Bone morphogenetic proteins (BMP) and Wnt induce the differentiation of mesenchymal cells toward osteoblasts, and insulin-like growth factor (IGF)-I stimulates the function of mature osteoblasts and prevents their death. The activity of BMP, Wnt and IGF-I is modulated by extracellular antagonists or binding proteins. Changes in growth factor synthesis and activity may play a role in the pathogenesis of selected forms of osteoporosis, and alterations in the expression or binding of the extracellular antagonists can be associated with changes in bone mass. Current approaches to bone anabolic therapies for osteoporosis include the administration of a growth factor, such as IGF-I, or the neutralization of an antagonist. Ideally, the targeting of an anabolic agent should be specific to bone to preclude non-skeletal unwanted side effects. Clinical trials are needed to determine the long-term effectiveness and safety of novel anabolic agents for the management of osteoporosis.
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影响因子：
4
作者：
BEAMER, WG;EICHER, EM
通讯作者：
EICHER, EM
影响因子：
15.9
作者：
CANALIS, E
通讯作者：
CANALIS, E
影响因子：
4.8
作者：
Devlin, RD;Du, Z;Canalis, E
通讯作者：
Canalis, E
影响因子：
--
作者：
Bodine, PVN;Zhao, WG;Komm, BS
通讯作者：
Komm, BS
影响因子：
4.8
作者：
Akeno, N;Robins, J;Clemens, TL
通讯作者：
Clemens, TL