Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR
Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR
复制标题
DOI：
10.1002/gps.2334
复制
发表时间：
2010-03-01
影响因子：
4
通讯作者：
Potter, Huntington
中科院分区：
文献类型：
--
作者：
Duara, Ranjan;Loewenstein, David A.;Potter, Huntington
目的：要检查的mCDR的信度和效度，修改版本的临床痴呆症评级（CDR）scale.Methods：mCDR是一个以信息为基础的，技术人员管理的，结构化的采访与多项选择回答，其中不包括客观的认知测试。对无认知功能障碍（NCI）、遗忘型轻度认知功能障碍（aMCI）和痴呆的受试者（n = 556）进行mCDR、CDR和神经心理学评估，同时在MRI扫描上测量内侧颞叶萎缩（MTA）。mCDR和CDR进行了比较，评分员之间的可靠性，有效性和能力，以预测在12个月follow-up.Results的认知诊断进展：mCDR可以在不到三分之一的时间管理CDR（30分钟）所需的管理。mCDR和CDR的评定者间可靠性（Cohen加权K）分别为0.86和0.56。与mCDR相比，CDR区分NCI、aMCI和痴呆受试者的能力以及与记忆和非记忆测量的相关性略好。mCDR和CDR评分与MTA评分的相关性无差异。基线mCDR评分预测从NCI过渡到aMCI，而基线CDR评分预测从aMCI过渡到Dementia.Conclusions：mCDR，相比CDR，是更简短，更可靠的，是一个有效的措施，功能正常的认知，轻度认知障碍，轻度痴呆症之间的能力。mCDR作为评估功能能力变化的可靠且经济的工具应特别有用，特别是在MCI和轻度痴呆的多中心临床试验和人群研究中。版权所有（C）2009约翰威利父子有限公司
Objective: To examine the reliability and validity of the mCDR, a modified version of the clinical dementia rating (CDR) scale.Methods: The mCDR is an informant-based, technician-administered, structured interview with multiple choice responses, which does not include objective cognitive testing. Subjects (n = 556) with no cognitive impairment (NCI), amnestic mild cognitive impairment (aMCI), and dementia were assessed with mCDR, CDR, and neuropsychological evaluation, while medial temporal atrophy (MTA) was measured on MRI scans. The mCDR and CDR were compared with respect to inter-rater reliability, validity, and ability to predict progression in cognitive diagnosis at 12 month follow-up.Results: The mCDR can be administered in less than one third of the time required to administer the CDR (30 min). Inter-rater reliability (Cohen's weighted K) was 0.86 for the mCDR and 0.56 for the CDR. Ability to distinguish between NCI, aMCI, and Dementia subjects, and correlations to memory and non-memory measures were marginally better for the CDR, in comparison to the mCDR. Correlations of mCDR and CDR scores to MTA scores did not differ. Baseline mCDR scores predicted transition from NCI to aMCI, whereas baseline CDR scores predicted transition from aMCI to Dementia.Conclusions: The mCDR, as compared to the CDR, is briefer and more reliable, and is a valid measure of functional ability among subjects with normal cognition, mild cognitive impairment, and mild dementia. The mCDR should be particularly useful as a reliable and economical instrument for assessing change in functional abilities, especially in multi-center clinical trials and population studies of MCI and mild dementia. Copyright (C) 2009 John Wiley & Sons, Ltd.