Intact interval timing in circadian CLOCK mutants
Intact interval timing in circadian CLOCK mutants
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DOI：
10.1016/j.brainres.2008.06.043
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发表时间：
2008-08-28
期刊：
影响因子：
2.9
通讯作者：
Gallistel, C. R.
中科院分区：
文献类型：
--
作者：
Cordes, Sara;Gallistel, C. R.
虽然在确定生物钟的分子基础方面取得了进展，但哺乳动物大脑以秒到分钟为单位测量时间间隔的机制仍然是一个谜。一个明显的问题是，间隔计时机制是否与昼夜节律计时机制共享分子机制。在目前的研究中，我们用10秒和20秒标准的峰值间隔程序训练昼夜节律时钟+/-和-/-突变雄性小鼠。突变小鼠比它们的野生型同伴更活跃，但与野生型同伴相比，它们在时间的准确性或精确性方面没有可靠的缺陷。这表明CLOCK蛋白的表达对于正常的间隔时间并不是必需的。(C) 2008 Elsevier B.V.版权所有
While progress has been made in determining the molecular basis for the circadian clock, the mechanism by which mammalian brains time intervals measured in seconds to minutes remains a mystery. An obvious question is whether the interval-timing mechanism shares molecular machinery with the circadian timing mechanism. In the current study, we trained circadian CLOCK +/- and -/- mutant male mice in a peak-interval procedure with 10 and 20-s criteria. The mutant mice were more active than their wild-type littermates, but there were no reliable deficits in the accuracy or precision of their timing as compared with wild-type littermates. This suggests that expression of the CLOCK protein is not necessary for normal interval timing. (C) 2008 Elsevier B.V. All rights reserved.