Roles of DGKs in neurons: Postsynaptic functions?
Roles of DGKs in neurons: Postsynaptic functions?
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DOI：
10.1016/j.jbior.2019.100688
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发表时间：
2020-01-01
影响因子：
--
通讯作者：
Raben, Daniel M.
中科院分区：
文献类型：
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作者：
Barber, Casey N.;Raben, Daniel M.
二酰甘油激酶 (DGK) 是细胞内信号传导的重要组成部分，因为除了降低二酰甘油水平外，它们还产生磷脂酸 (PtdOH)。最近的研究发现了 10 种哺乳动物 DGK 亚型，所有这些亚型都存在于哺乳动物大脑中。许多同种型已经研究了大脑内的功能，而其他同种型则缺乏对神经元作用、调节和结构动力学的了解。然而，虽然以前 DGK theta 的神经元功能尚不清楚，但最近发现 DGK theta 是调节突触小泡内吞作用所必需的，目前正在进行工作以阐明这种调节背后的机制。在这里，我们将回顾所有哺乳动物 DGK 的一些作用并假设其他作用。我们将讨论十种 DGK 同工型之间的冗余问题，并讨论 DGK theta 和其他 DGK 中可能具有未经研究的突触后功能的可能性。我们还假设，除了 DGK theta 的突触前内吞作用外，DGK theta 还可能调节 AMPA 受体和其他突触后膜蛋白的内吞作用。
Diacylglycerol kinases (DGKs) contribute to an important part of intracellular signaling because, in addition to reducing diacylglycerol levels, they generate phosphatidic acid (PtdOH) Recent research has led to the discovery of ten mammalian DGK isoforms, all of which are found in the mammalian brain. Many of these isoforms have studied functions within the brain, while others lack such understanding in regards to neuronal roles, regulation, and structural dynamics. However, while previously a neuronal function for DGK theta was unknown, it was recently found that DGK theta is required for the regulation of synaptic vesicle endocytosis and work is currently being conducted to elucidate the mechanism behind this regulation. Here we will review some of the roles of all mammalian DGKs and hypothesize additional roles. We will address the topic of redundancy among the ten DGK isoforms and discuss the possibility that DGK theta, among other DGKs, may have unstudied postsynaptic functions. We also hypothesize that in addition to DGK theta's presynaptic endocytic role, DGK theta might also regulate the endocytosis of AMPA receptors and other postsynaptic membrane proteins.