Subcutaneous Panniculitis-Like T-Cell Lymphoma in Two Pediatric Patients: An HIV-Positive Adolescent and a 4-Month-Old Infant
Subcutaneous Panniculitis-Like T-Cell Lymphoma in Two Pediatric Patients: An HIV-Positive Adolescent and a 4-Month-Old Infant
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两名儿童患者的皮下脂膜炎样 T 细胞淋巴瘤：一名 HIV 阳性青少年和一名 4 个月大的婴儿
DOI：
10.3109/15513815.2012.701264
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发表时间：
2013
影响因子：
1.1
通讯作者：
D. Cassarino
中科院分区：
文献类型：
--
作者：
Sara C. Acree;J. Tovar;P. Pattengale;Larry L. Wang;J. Church;P. Gaynon;D. Cassarino
皮下脂膜炎样T细胞淋巴瘤(SPTCL)是一种罕见的儿童非霍奇金淋巴瘤亚型。皮下脂膜炎样T细胞淋巴瘤是一种与噬血细胞综合征(HPS)相关的侵袭性变异。与其他T细胞淋巴瘤不同，没有HPS的患者使用泼尼松或免疫抑制治疗可显示出疾病的缓解。1例HIV阳性青少年和1例婴儿合并多发性皮下肿块，并复习文献。皮损细胞符合SPTCLα-β型。我们的病例，在没有HPS的情况下，在非侵袭性治疗下，他们的皮损完全消失。SPTCLα-β综合征患者应保守治疗。
Subcutaneous Panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of childhood non-Hodgkin lymphoma. Subcutaneous Panniculitis-like T-cell lymphoma has an aggressive variant associated with the hemophagocytic syndrome (HPS). Patients without HPS show resolution of the disease with prednisone or immunosuppressive therapy unlike other T-cell lymphomas. One HIV-positive adolescent and one infant with multiple subcutaneous masses are presented and the literature is reviewed. Lesional cells were consistent with SPTCL alpha-beta type. Our cases, without HPS, showed complete resolution of their lesions when treated with non-aggressive therapies. Patients with SPTCL alpha-beta should be treated conservatively.