Simultaneous EEG and functional MRI of epileptic activity: a case report
Simultaneous EEG and functional MRI of epileptic activity: a case report
复制标题
DOI：
10.1016/s1388-2457(01)00562-4
复制
发表时间：
2001-07-01
影响因子：
4.7
通讯作者：
Frahm, J
中科院分区：
文献类型：
--
作者：
Baudewig, J;Bittermann, HJ;Frahm, J
目的：尝试通过将脑电图 (EEG) 异常与蓝色氧合水平依赖性 (BOLD) 磁共振成像 (MRI) 信号改变联系起来来定位癫痫活动的来源：主要受到 MRI 期间脑电图失真、受试者运动和未知血流动力学反应特征的阻碍。方法：使用 2.0 T 的 T2* 加权回波平面成像（2 s 时间分辨率，2x2x4 mm(3) 空间）分辨率）。这项工作展示了在研究具有多尖峰和慢波复合体的特发性全身性癫痫患者时缓解其中一些问题的策略。结果：动态 MRI 期间的连续 EEG 记录（500 ms 扫描，1500 ms 延迟）和检查后用于 MRI 分析的 EEG 参考函数的推导显示出阳性 BOLD MRI 反应，其时间特征与获得的毛功能挑战相似。结论：绘制局灶性癫痫活动的能力和/或相关的认知处理为癫痫研究和临床患者管理提供了新的潜力。 (C) 2001 Elsevier Science Ireland Ltd. 我保留所有权利。
Objectives: Attempts to localize the source of epileptic activity by linking electroencephalographic (EEG) abnormalities to blued oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) signal alterations art: hampered mainly by EEG distortions during MRI, subject motion, and unknown hemodynamic response characteristics.Methods: Using T2*-weighted echo-planar imaging at 2.0 T (2 s temporal resolution, 2x2x4 mm(3) spatial resolution). this work demonstrates strategies to alleviate some of these problems while studying a patient who had ideopathic generalized epilepsy with polyspike and slow-wave complexes.Results: Continuous EEG recordings during dynamic MRI (500 ms scanning, 1500 ms delay) and post-examination derivation of an EEG reference function for MRI analysis revealed positive BOLD MRI responses with temporal characteristics similar to those obtained fur functional challenges.Conclusions: The ability to map focal epileptic activity and/or associated cognitive processing provides new potential fur both epilepsy research and clinical patient management. (C) 2001 Elsevier Science Ireland Ltd. All rights I reserved.