No consistent effect of cerebellar transcranial direct current stimulation on visuomotor adaptation
No consistent effect of cerebellar transcranial direct current stimulation on visuomotor adaptation
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DOI：
10.1152/jn.00896.2016
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发表时间：
2017-08-01
影响因子：
2.5
通讯作者：
Galea, Joseph M.
中科院分区：
文献类型：
--
作者：
Jalali, Roya;Miall, R. Chris;Galea, Joseph M.
小脑经颅直流电刺激（ctDCS）被认为可以增强对一种新的视觉旋转（视觉运动适应）的适应，并且被认为是一种有希望的治疗干预。然而，尚不清楚这种效应是否在不同的任务参数中具有鲁棒性。如果ctDCS要用于临床，这个问题是至关重要的，因为它必须在相对广泛的行为范围内具有一致和强大的效果。本研究的目的是检查ctDCS对视觉运动适应的影响，这些适应是系统变化的任务参数。因此，192名年轻健康个体参加了7个视觉运动适应实验中的1个，无论是在正常或假ctDCS组。每个实验都检查了当任务的一个独特特征被改变时，ctDCS是否对适应有积极影响：监视器的位置、脱机tDCS、工具的使用和扰动时间表。虽然我们最初重复了之前报道的ctDCS对视觉运动适应的积极作用，但在第二次重复研究中或在大范围的不同任务参数中，这一结果并未得到维持。至少，这可能会质疑在临床环境中使用ctDCS的有效性，因为需要在整个行为中产生稳健和一致的效果。小脑经颅直流电刺激（ctDCS）已知可增强运动适应，因此有望作为一种治疗干预手段。然而，了解ctDCS在不同任务参数中的可靠性是至关重要的。为了检验这一点，我们研究了ctDCS是否在一系列不同的任务参数中增强了视觉运动适应。我们发现ctDCS对视觉运动适应没有一致的影响，质疑在临床背景下使用ctDCS的有效性。
Cerebellar transcranial direct current stimulation (ctDCS) is known to enhance adaptation to a novel visual rotation (visuomotor adaptation), and it is suggested to hold promise as a therapeutic intervention. However, it is unknown whether this effect is robust across varying task parameters. This question is crucial if ctDCS is to be used clinically, because it must have a consistent and robust effect across a relatively wide range of behaviors. The aim of this study was to examine the effect of ctDCS on visuomotor adaptation across a wide range of task parameters that were systematically varied. Therefore, 192 young healthy individuals participated in 1 of 7 visuomotor adaptation experiments in either an anodal or sham ctDCS group. Each experiment examined whether ctDCS had a positive effect on adaptation when a unique feature of the task was altered: position of the monitor, offline tDCS, use of a tool, and perturbation schedule. Although we initially replicated the previously reported positive effect of ctDCS on visuomotor adaptation, this was not maintained during a second replication study or across a large range of varying task parameters. At the very least, this may call into question the validity of using ctDCS within a clinical context where a robust and consistent effect across behavior would be required.NEW & NOTEWORTHY Cerebellar transcranial direct current stimulation (ctDCS) is known to enhance motor adaptation and thus holds promise as a therapeutic intervention. However, understanding the reliability of ctDCS across varying task parameters is crucial. To examine this, we investigated whether ctDCS enhanced visuomotor adaptation across a range of varying task parameters. We found ctDCS to have no consistent effect on visuomotor adaptation, questioning the validity of using ctDCS within a clinical context.