IONIC FACTORS IN RELEASE OF CA-45(2+) FROM CHICKEN CEREBRAL TISSUE BY ELECTROMAGNETIC-FIELDS
IONIC FACTORS IN RELEASE OF CA-45(2+) FROM CHICKEN CEREBRAL TISSUE BY ELECTROMAGNETIC-FIELDS
复制标题
DOI：
10.1073/pnas.75.12.6314
复制
发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
SABBOT, IM
中科院分区：
文献类型：
--
作者：
BAWIN, SM;ADEY, WR;SABBOT, IM
射频调幅电刺激可增加鸡脑组织45Ca~(2+)外流。这种反应对浴液中钙离子浓度(0.108-4.16 mM)的变化不敏感，但在没有正常碳酸氢盐浓度(2.4mM)的情况下，H+离子(2.4mMHCl)的加入可增强该反应，而抑制该反应。在无碳酸氢盐溶液中加入La可恢复电反应，但刺激减少而不是增加45Ca~(2+)外流。低频率、弱的胞外电场梯度可能在一类特殊的胞外负结合部位被转导，通常由钙离子占据，并容易受到竞争性H+结合的影响。
Electrical stimulation with radiofrequency fields amplitude-modulated at brain wave frequencies increased 45Ca2+ efflux from isolated chicken cerebral tissue. The response was not sensitive to variations of the Ca concentration (0-4.16 mM) in the bathing solution but was enhanced by addition of H+ (0.108 mM HCl) and inhibited in the absence of normal bicarbonate levels (2.4 mM). Addition of La to the bicarbonate-free solution restored electrical responsiveness, but the stimulus decreased instead of increasing 45Ca2+ efflux. Low-frequency, weak, extracellular electric gradients may be transduced in a specific class of extracellular negative binding sites normally occupied by Ca2+ and susceptible to competitive H+ binding.