Acoustic determination of early stages of intravascular blood coagulation
Acoustic determination of early stages of intravascular blood coagulation
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DOI：
10.1098/rsta.2008.0109
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发表时间：
2008-10
期刊：
影响因子：
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通讯作者：
S. G. Uzlova;Konstantin G. Guria;G. Guria
中科院分区：
文献类型：
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作者：
S. G. Uzlova;Konstantin G. Guria;G. Guria
血液凝固系统（BCS）是一个复杂的生物系统，在维持止血中起着重要作用。BCS活性不足可能导致出血和失血（例如血友病）。另一方面，过度活动可能导致血管内血液凝固、血栓形成和栓塞。目前用于BCS监测的大多数方法都存在侵入性的主要缺点。本工作的目的是证明使用超声方法的可行性，在密集的流动的血液凝固过程的早期阶段的非侵入性注册。为此，设计了一种特殊的实验装置，便于在凝血过程中同时检测光学和声学信号。结果表明，（i）在血液凝固的早期阶段，随着微栓子出现在血流中，多普勒信号的强度增加两倍，以及（ii）血液凝固早期阶段的微栓子形成总是通过声学对比显示出来。这两种效应都是明确的，因此我们希望它们可以用于临床实践中的无创BCS监测。
The blood coagulation system (BCS) is a complex biological system playing a principal role in the maintenance of haemostasis. Insufficient activity of the BCS may lead to bleeding and blood loss (e.g. in the case of haemophilia). On the other hand, excessive activity may cause intravascular blood coagulation, thromboses and embolization. Most of the methods currently used for BCS monitoring suffer from the major disadvantage of being invasive. The purpose of the present work is to demonstrate the feasibility of using ultrasonic methods for non-invasive registration of the early stages of blood coagulation processes in intensive flows. With this purpose, a special experimental set-up was designed, facilitating the simultaneous detection of optical and acoustic signals during the clotting process. It was shown that (i) as microemboli appear in the flow during the early stage of blood coagulation, the intensity of the Doppler signal increases twofold, and (ii) microemboli formation in the early stages of blood clotting always reveals itself through an acoustic contrast. Both of these effects are well defined, so we hope that they may be used for non-invasive BCS monitoring in clinical practice.