Prefrontal acetylcholine release controls cue detection on multiple timescales
Prefrontal acetylcholine release controls cue detection on multiple timescales
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DOI：
10.1016/j.neuron.2007.08.025
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发表时间：
2007-10-04
期刊：
影响因子：
16.2
通讯作者：
Sarter, Martin
中科院分区：
文献类型：
--
作者：
Parikh, Vinay;Kozak, Rouba;Sarter, Martin
胆碱能神经元起源于基底前脑，支配整个皮质地幔。采用胆碱敏感微电极在亚秒分辨率下测量大鼠执行涉及线索检测的任务时皮层乙酰胆碱（ACh）的突触释放。被检测到的、行为上定义的线索，在内侧前额叶皮层（mPFC）诱发了短暂的胆碱能活动增加（以秒为单位），但在非关联控制区（运动皮层）则没有。在涉及遗漏线索的试验中，未观察到胆碱能瞬变。中脑皮层的胆碱能传递障碍，而不是运动皮层，导致线索检测受损。此外，前胆碱能活性的降低和增加分别预测了随后的线索检测或遗漏。最后，线索诱发的胆碱能瞬态叠加在较慢的胆碱能活性变化上（以分钟为时间尺度）。皮层胆碱能神经传递在多个时间尺度上调节，以介导对行为显著线索的检测并支持认知表现。
Cholinergic neurons originating from the basal forebrain innervate the entire cortical mantle. Choline-sensitive microelectrodes were used to measure the synaptic release of cortical acetylcholine (ACh) at a subsecond resolution in rats performing a task involving the detection of cues. Cues that were detected, defined behaviorally, evoked transient increases in cholinergic activity (at the scale of seconds) in the medial prefrontal cortex (mPFC), but not in a nonassociational control region (motor cortex). In trials involving missed cues, cholinergic transients were not observed. Cholinergic deafferentation of the mPFC, but not motor cortex, impaired cue detection. Furthermore, decreases and increases in precue cholinergic activity predicted subsequent cue detection or misses, respectively. Finally, cue-evoked cholinergic transients were superimposed over slower (at the timescale of minutes) changes in cholinergic activity. Cortical cholinergic neurotransmission is regulated on multiple timescales to mediate the detection of behaviorally significant cues and to support cognitive performance.