Increased insula coactivation with salience networks in insomnia.
Increased insula coactivation with salience networks in insomnia.
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DOI：
10.1016/j.biopsycho.2013.12.016
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发表时间：
2014-03
影响因子：
2.6
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Chen, Michael C.;Chang, Catie;Glover, Gary H.;Gotlib, Ian H.
失眠是所有睡眠相关疾病中最普遍和最昂贵的。为了描述失眠症主观功能障碍的神经机制，我们使用功能性磁共振成像（fMRI）和脑电图（EEG）同时检查了17名女性失眠症患者和17名女性健康对照者在休息和试图入睡时的大脑活动。在研究内在脑网络内的动态区域活动时，我们发现，与对照组相比，失眠症患者的前额叶与显著性网络的参与程度更高，失眠症患者在休息期间与EEG伽马频率功率的相关性也更高。失眠症患者的前额叶受累增加与负面情绪有关。在唤醒网络中，整合时间和身体状态的脑皮层的异常激活可能是失眠症患者对睡眠质量和主观痛苦的误解的基础。
Insomnia is among the most prevalent and costly of all sleep-related disorders. To characterize the neural mechanisms underlying subjective dysfunction in insomnia, we examined brain activity in 17 female insomniacs and 17 female healthy controls using simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) while they were resting and while they were trying to fall asleep. In examining the dynamic regional activity within intrinsic brain networks, we found that, compared with controls, insomniacs had greater involvement of the anterior insula with salience networks, as well as insula BOLD correlation with EEG gamma frequency power during rest in insomniacs. This increased involvement of the anterior insula was associated with negative affect in insomniacs. Aberrant activation of the insula, which integrates temporal and bodily states, in arousal networks may underlie the misperception of sleep quality and subjective distress in insomnia.
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影响因子：
120.7
作者：
Edinger, JD;Wohlgemuth, WK;Quillian, RE
通讯作者：
Quillian, RE
DOI：
10.1523/jneurosci.1809-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cano G;Mochizuki T;Saper CB
通讯作者：
Saper CB
DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.
影响因子：
--
作者：
Edinger, Jack D.;Wyatt, James K.;Krystal, Andrew D.
通讯作者：
Krystal, Andrew D.