Progress toward synthesis of diazonamide A. Preparation of a 3-(oxazol-5-yl)-4-trifluoromethyl-sulfonyloxyindole and its use in biaryl coupling reactions.
Progress toward synthesis of diazonamide A. Preparation of a 3-(oxazol-5-yl)-4-trifluoromethyl-sulfonyloxyindole and its use in biaryl coupling reactions.
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DOI：
10.1021/ol005548p
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发表时间：
2000-03
期刊：
影响因子：
5.2
通讯作者：
E. Vedejs;D. Barda
中科院分区：
文献类型：
--
作者：
E. Vedejs;D. Barda
[分子式：见正文]描述了3-恶唑-5-基-吲哚-4-三氟甲磺酸酯的合成，其特征在于制备恶唑的Schölkopf反应。此外，该中间体的参与联芳基偶联反应对天然产物重氮酰胺A的全合成。
[formula: see text] The synthesis of a 3-oxazol-5-yl-indole-4-triflate is described, featuring a Schölkopf reaction to prepare the oxazole. In addition, the participation of this intermediate in biaryl coupling reactions toward the total synthesis of the natural product diazonamide A is presented.