The influences of ambient fine particulate matter constituents on plasma hormones, circulating TMAO levels and blood pressure: A panel study in China
The influences of ambient fine particulate matter constituents on plasma hormones, circulating TMAO levels and blood pressure: A panel study in China
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环境细颗粒物成分对血浆激素、循环TMAO水平和血压的影响：中国的一项小组研究
DOI：
10.1016/j.envpol.2021.118746
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Chen Rui
中科院分区：
文献类型：
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作者：
Wang Jiajia;Wu Shenshen;Cui Jian;Ding Zhen;Meng Qingtao;Sun Hao;Li Bin;Teng Jun;Dong Yanping;Aschner Michael;Wu Shaowei;Li Xiaobo;Chen Rui
针对高血压患者环境细颗粒物（PM2.5）与血压（BP）之间的关系进行了大量调查。然而，很少有研究探讨pm2.5及其成分对三甲胺n -氧化物（TMAO）的影响，TMAO是高血压和心血管疾病（CVD）的既定危险因素，特别是在严重空气污染地区。为了探讨pm2.5成分对血压、血浆激素和氧化三甲胺的潜在影响，我们进行了一项小组研究，研究了1期高血压年轻人暴露于环境空气污染后血压、血浆激素和氧化三甲胺的变化。采用线性混合效应模型估计细颗粒物（PM2.5）及其组分对血压、血浆激素和TMAO的累积效应。我们发现，0-1天移动平均pm2.5浓度增加1个四分位数范围（IQR） （35 μg/m3）与收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）升高有统计学意义，其估计值分别为0.13(95%置信区间（CI）： 0.03 ~ 0.23) mmHg、0.18 (95% CI: 0.08 ~ 0.28) mmHg和0.17 (95% CI: 0.09 ~ 0.26) mmHg。肾素-血管紧张素-醛固酮系统的激素紊乱也与pm2.5暴露有关。pm2.5移动平均浓度为0-4、0-5、0-6时，TMAO水平随IQR增加而升高，升高值为26.28 (95% CI: 2.92 ~ 49.64) ~ 60.78 (31.95 ~ 89.61) ng/ml。更重要的是，pm2.5结合的金属成分，如锰（Mn）、钛（Ti）和硒（Se）显示出与血压升高和血浆TMAO水平的强烈关联。这项研究表明，在1期高血压的年轻人中，pm2.5金属成分与血压升高、血浆激素和氧化三甲胺的变化之间存在关联。应实施污染源控制，旨在减少pm2.5结合金属的排放，以降低高血压和心血管疾病的风险。
Considerable investigations have been carried out to address the relationship between ambient fine particulate matter (PM2.5) and blood pressure (BP) in patients with hypertension. However, few studies have explored the influence of PM2.5and its constituents on Trimethylamine N-oxide (TMAO), an established risk factor for hypertension and cardiovascular disease (CVD), particularly in severely air-polluted areas. To explore the potential impact of PM2.5constituents on BP, plasma hormones, and TMAO, a panel study was conducted to investigate changes in BP, plasma hormones, and TMAO in response to ambient air pollution exposure in stage 1 hypertensive young adults. Linear mixed effect models were used to estimate the cumulative effects of fine particulate matters (PM2.5) and its constituents on BP, plasma hormones and TMAO. We found that one interquartile range (IQR) (35 μg/m3) increase in 0–1 day moving-average PM2.5concentrations was statistically significantly associated with elevated systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) with estimated values of 0.13 (95% confidence interval (CI): 0.03 to 0.23) mmHg, 0.18 (95% CI: 0.08 to 0.28) mmHg, and 0.17 (95% CI: 0.09 to 0.26) mmHg, respectively. Hormone disturbance in the renin-angiotensin-aldosterone system was also associated with PM2.5exposure. Elevated TMAO levels with an IQR increase for 0–4, 0–5, 0–6 moving-average concentrations of PM2.5were found, and the increased values ranged from 26.28 (95% CI: 2.92 to 49.64) to 60.78 (31.95–89.61) ng/ml. More importantly, the PM2.5-bound metal constituents, such as manganese (Mn), titanium (Ti), and selenium (Se) showed robust associations with elevated BP and plasma TMAO levels. This study demonstrates associations between PM2.5metal constituents and increased BP, changes in plasma hormones and TMAO, in stage 1 hypertensive young adults. Source control, aiming to reduce the emission of PM2.5-bound metals should be implemented to reduce the risk of hypertension and CVD.