Transepidermal Potential of the Stretched Skin
Transepidermal Potential of the Stretched Skin
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DOI：
10.1115/1.4043522
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发表时间：
2019-08-01
影响因子：
1.7
通讯作者：
Nishizawa, Matsuhiko
中科院分区：
文献类型：
--
作者：
Abe, Yuina;Konno, Hajime;Nishizawa, Matsuhiko
这里报告了皮肤对机械拉伸的电响应。穿过表皮的电位差，即，通过真实的实时测量周期性牵张作用下猪皮的经皮电位（TEP），观察表皮组织的电化学变化。除了用于整个皮肤样品的TEP测量的常规方法之外，使用具有细针盐桥的探针型系统来直接测量皮肤的目标局部点处的TEP。TEP随机械拉伸的增加而降低，常规方法与探针式方法的结果比较发现，TEP的变化主要发生在表皮，而不是真皮或下皮。观察到的TEP值的变化是快速的，可逆的，应变依赖性。从这些特征行为考虑，TEP的调制的可能机制之一将是在表皮的物理变形期间由流体流动引起的流动电位的影响。
The electrical response of the skin to mechanical stretches is reported here. The electrical potential difference across the epidermis, i.e., transepidermal potential (TEP) of porcine skin samples subjected to cyclic stretching, was measured in real time to observe electrochemical change in epidermal tissue. In addition to a conventional method of TEP measurement for the whole of skin sample, a probe-type system with a fine-needle salt bridge was used for direct measurement of TEP at a targeted local point of the skin. TEP decreased with the increased mechanical stretches, and the change of TEP was found to be mostly occurred in the epidermis but not dermis nor hypodermis by comparing the results of conventional and the probe-type methods. The observed change of TEP value was quick, reversible, and strain-dependent. Considering from such characteristic behaviors, one of the possible mechanisms of the modulation of TEP would be influence of the streaming potential caused by the fluid flow during the physical deformation of the epidermis.