Cerebral activation during performance of a card sorting test
Cerebral activation during performance of a card sorting test
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DOI：
10.1093/brain/119.5.1667
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发表时间：
1996-10-01
期刊：
影响因子：
14.5
通讯作者：
Kimura, J
中科院分区：
文献类型：
--
作者：
Nagahama, Y;Fukuyama, H;Kimura, J
威斯康星卡片分类测验(WCST)在临床上用于评估额叶功能，但其对额叶损害的特异性尚有争议。为了研究卡片分类测验的脑区功能，我们用正电子发射计算机断层扫描(PET)测量了18名正常人在三种条件下的局部脑血流量(RCBF)：(I)在改良卡片分类测验(MCST)中；(Ii)在匹配样本(MTS)任务中，以MCST为基础，但以选择性注意三种刺激类别(颜色数量或形状)中的一种为对照，以抵消静息条件下MCST中集合维持的影响作为总体对照。比较MCST与各MTS任务时的rCBF，分别在左侧或双侧背外侧前额叶(DLPFC)、双侧顶下叶、左侧枕上回和左侧小脑观察到显著激活。与所有MTS任务相比，MCST期间双侧DLPFC、顶下叶、纹状皮质、小脑和左侧枕叶的rCBF显著增加。这些结果表明，DLPFC和其他相关区域，如顶下皮质参与了MCST的执行：并可能有助于解释为什么各种脑损伤会导致卡片分类测试中的表现受损。
The Wisconsin Card Sorting Test (WCST) is used clinically for evaluating frontal lobe function, but there is some controversy as to its specificity for detecting frontal lobe damage. To investigate the cerebral regions essential to the performance of the Card Sorting Test, we measured the regional cerebral blood pow (rCBF) in 18 normal subjects by PET under the three conditions: (i) during the Modified Card Sorting Test (MCST); (ii) during a matching-to-sample (MTS) task, based on the MCST: but with selective attention to one of three stimulus categories (colour number or shape) as a control to cancel the effects of maintenance of sets in the MCST (iii) under resting conditions as overall control. When rCBF during the MCST was compared with that during each MTS task separately significant activations were observed during the MCST in the left or bilateral dorsolateral prefrontal cortex (DLPFC), bilateral inferior parietal lobes, left superior occipital gyrus and left cerebellum. Compared with all the MTS tasks inclusively, significant increase in rCBF was detected during the MCST in the bilateral DLPFC, inferior parietal lobes, striate cortex, cerebellum and left occipital cortex. These results suggest the involvement of the DLPFC and other related areas such as the inferior parietal cortex in the execution of the MCST: and may help explain why a variety of brain lesions can result in impaired performance on the Card Sorting Test.