Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells
Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells
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DOI：
10.1007/s13277-013-0679-1
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发表时间：
2013-06-01
期刊：
影响因子：
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通讯作者：
Lou, Wenhui
中科院分区：
文献类型：
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作者：
Rong, Yefei;Wu, Wenchuan;Lou, Wenhui
胰腺癌的预后非常差，需要为这种癌症开发新的治疗策略。近年来，瓦尔堡效应（有氧糖酵解）因其在肿瘤发生中的作用而受到广泛关注。乳酸脱氢酶A（LDHA）执行有氧糖酵解的最后一步，并已被报道参与肿瘤的进展。然而，LDHA在胰腺癌中的功能尚未研究。在此，我们发现LDHA的表达在临床胰腺癌样品中升高。LDHA的强制表达促进胰腺癌细胞的生长，而敲低LDHA的表达则显著抑制细胞的生长。此外，沉默LDHA的表达抑制胰腺癌细胞在体内的致瘤性。机制上，敲低LDHA的表达激活凋亡途径。总之，我们的研究揭示了LDHA在胰腺癌中的致癌作用，并建议LDHA可能是一个潜在的治疗靶点。
The prognosis for pancreatic cancer is very poor, and developing new therapeutic strategies for this cancer is needed. Recently, the Warburg effect (aerobic glycolysis) has attracted much attention for its function in the tumorigenesis. Lactate dehydrogenase A (LDHA) executes the final step of aerobic glycolysis and has been reported to be involved in the tumor progression. However, the function of LDHA in pancreatic cancer has not been studied. Here, we found that the expression of LDHA was elevated in the clinical pancreatic cancer samples. Forced expression of LDHA promoted the growth of pancreatic cancer cells, while knocking down the expression of LDHA inhibited cell growth dramatically. Moreover, silencing the expression of LDHA inhibited the tumorigenicity of pancreatic cancer cells in vivo. Mechanistically, knocking down the expression of LDHA activated apoptosis pathway. Taken together, our study revealed the oncogenic role of LDHA in pancreatic cancer and suggested that LDHA might be a potential therapeutic target.