CLINICAL AND ULTRASTRUCTURAL CORRELATIONS IN NASAL MUCOCILIARY FUNCTION OBSERVED IN CHILDREN WITH RECURRENT AIRWAYS INFECTIONS
CLINICAL AND ULTRASTRUCTURAL CORRELATIONS IN NASAL MUCOCILIARY FUNCTION OBSERVED IN CHILDREN WITH RECURRENT AIRWAYS INFECTIONS
复制标题
DOI：
10.1016/0165-5876(95)01133-v
复制
发表时间：
1995-05-01
影响因子：
1.5
通讯作者：
BASTERRA, J
中科院分区：
文献类型：
--
作者：
ARMENGOT, M;ESCRIBANO, A;BASTERRA, J
对106名1 ~ 15岁（平均6岁）的儿童进行了研究，这些儿童自出生以来就患有反复的上呼吸道和下呼吸道感染;通过Tc 99 m标记的血清白蛋白技术测定了所有受试者的鼻粘膜纤毛运输（NMT）速度。在42名儿童中，NMT被发现改变。在这组患者中，在1至2年后重复该技术。23例（55%）转运恢复正常，19例（45%）转运仍有改变，本组中复发性肺炎和持续性鼻漏更常见。仅在2例患者中检测到逆位。病理学显示纤毛超微结构，动力蛋白臂缺失和微管改变。在一些患者中观察到纤毛缺失，在持续改变鼻粘膜纤毛运输的儿童中也遇到正常纤毛。
A study was made of 106 children between 1 and 15 years of age (mean 6 years) with recurrent upper and lower airways infections since birth; Nasal mucociliary transport (NMT) velocity was determined in all subjects by the Tc99m-labeled seroalbumin technique. In 42 children, NMT was found to be altered. In this group of patients the technique was repeated in a period of between 1 and 2 years later. In 23 cases (55%) transport had normalized, while in 19 (45%) it remained altered, Recurrent pneumonia and constant rhinorrhea were more frequent in this group. Situs inversus was only detected in 2 of these patients. Pathology showed ciliary ultrastructure, the absence of dynein arms and microtubule alterations. The absence of cilia was observed in some patients, Normal cilia were also encountered in children with persistently altered nasal mucociliary transport.