Perineuronal nets: past and present
Perineuronal nets: past and present
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DOI：
10.1016/s0166-2236(98)01298-3
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发表时间：
1998-12-01
影响因子：
15.9
通讯作者：
Vitellaro-Zuccarello, L
中科院分区：
文献类型：
--
作者：
Celio, MR;Spreafico, R;Vitellaro-Zuccarello, L
高尔基将贴附在神经细胞表面的外周网状结构与使他的名字永垂不朽的细胞内网或高尔基体并列。最初，这种外周网状结构或神经细胞周围网被认为是反复无常的染色技术的人工制品，现在被认为是神经细胞学中的真实实体。它代表细胞外基质分子的复合体，介于神经胶质突起和神经细胞表面之间，神经胶质突起之间无法区分它们。在神经科学的其他分支中，对任何形态实体的兴趣的兴衰都没有像神经周网络这样明显。这篇综述追溯了这一神秘结构从构思到现在的历史，揭示了世纪之交形态学者敏锐的观察能力，并揭示了他们敏锐的预见性如何先于当前对周围神经网作用的思考。
Golgi ranked the peripheral reticulum - which adheres intimately to nerve cell surfaces - alongside the intracellular reticulum, or Golgi apparatus,which immortalized his name.At first dismissed as an artefact of capricious staining techniques, this peripheral reticulum, or perineuronal net, is now recognized as a genuine entity in neurocytology. it represents a complex of extracellular matrix molecules interposed between the meshwork of glial processes, from which they are indistinguishable, and nerve-cell surfaces. In no other branch of neuroscience has the waxing and waning of interest in any morphological entity been so pronounced as in the case of the perineuronal net. This review traces the history of this enigmatic structure from its conception to the present time, brings to light the keen observational powers of morphologists at the turn of the century and reveals how their sagacious forethought anticipated current thinking on the role of perineuronal nets.