Substituted epoxides by lithiation of terminal epoxides.
Substituted epoxides by lithiation of terminal epoxides.
复制标题
通过末端环氧化物的锂化来取代环氧化物。
作者：
D. Hodgson;N. J. Reynolds;S. Coote
二胺配体辅助的直接氢锂交换可以产生非稳定的（h取代的）氧基锂，并随后被Bu(3)SnCl和羰基亲电试剂捕获。该反应为合成α、β -环氧烷和取代环氧化合物提供了一条新的简明途径。
Diamine-ligand-assisted direct hydrogen-lithium exchange allows the generation of nonstabilized (H-substituted) oxiranyllithium species and their subsequent trapping by Bu(3)SnCl and carbonyl-based electrophiles. This reaction provides a new concise route to alpha,beta-epoxystannanes and substituted epoxides.